Network Version
Product Name: | MG-101 | |
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CAS No.: | 110044-82-1 | |
Cat. No.: | HY-18964 | |
MWt: | 383.53 | |
Formula: | C20H37N3O4 | |
Purity : | >98% | |
Solubility: | DMSO : 16.67 mg/mL (43.46 mM; Need ultrasonic) | |
Mechanisms: | Target: Cancer | |
Biological Activity: | ||
MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer[1]. In Vitro: MG-101 (0-26 μM; 24 h) affects the growth of colon cancer HCT116 cells[1]. MG-101 (0-26 μM; 24 h) induces apoptosis of various cancer cells[1]. MG-101 (0-26 μM; 24 h) induces Bax-dependent apoptosis in HCT116 cells[1]. In Vivo: MG-101 (10 mg/kg; i.p. once daily for 15 days) inhibits tumor growth in nude mice[1]. |
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