Network Version
PND-1186 Data Sheet
| Product Name: | PND-1186 |
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|---|---|---|
| CAS No.: | 1061353-68-1 | |
| Cat. No.: | HY-13917 | |
| MWt: | 501.5 | |
| Formula: | C25H26F3N5O3 | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 34 mg/mL (67.80 mM) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
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PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis[1].
IC50 & Target: IC50: 1.5 nM (FAK)[1]
In Vitro: PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397[1]. In murine 4T1 breast carcinoma cells, FAK is important in promoting an invasive and metastatic cell phenotype. Increasing concentrations of PND-1186 (0.1 to 1.0 µM) added to 4T1 cells inhibits FAK Tyr-397 phosphorylation (pY397) and results in elevated levels of total FAK protein within 1 h[1]. In Vivo: PND-1186 (30 mg/kg or 100 mg/kg; subcutaneously; injected subcutaneously in the neck region) inhibits 4T1 subcutaneous tumor growth by induction of apoptosis[1]. |
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