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PTC-209 Data Sheet

Product Name: PTC-209
CAS No.: 315704-66-6
Cat. No.: HY-15888
MWt: 495.19
Formula: C17H13Br2N5OS
Purity : >98%
Solubility: DMSO : ≥ 32 mg/mL (64.62 mM)
Mechanisms: Target: Cancer
Biological Activity:
PTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment[1][2]. IC50 & Target: IC50: 0.5 μM (BMI-1, in HT1080 tumor cells)[1] In Vitro: PTC-209 (0.01-10 µM; 24-72 hours) induces a concentration- and time-dependent decrease in the cellular viability of all cell lines tested[2].
PTC-209 (1-2.5 μM) inhibits STAT3 phosphorylation in A549 lung cancer cells and MDA-MB-231 breast cancer cells[2]. In Vivo: PTC-209 (60 mg/kg body weight; subcutaneously; once a day for 11 days) significantly reduces tumor volume[1].

Caution: Not fully tested. For research purposes only

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