Network Version
Product Name: | PTC-209 | |
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CAS No.: | 315704-66-6 | |
Cat. No.: | HY-15888 | |
MWt: | 495.19 | |
Formula: | C17H13Br2N5OS | |
Purity : | >98% | |
Solubility: | DMSO : ≥ 32 mg/mL (64.62 mM) | |
Mechanisms: | Target: Cancer | |
Biological Activity: | ||
PTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment[1][2].
IC50 & Target: IC50: 0.5 μM (BMI-1, in HT1080 tumor cells)[1]
In Vitro: PTC-209 (0.01-10 µM; 24-72 hours) induces a concentration- and time-dependent decrease in the cellular viability of all cell lines tested[2]. PTC-209 (1-2.5 μM) inhibits STAT3 phosphorylation in A549 lung cancer cells and MDA-MB-231 breast cancer cells[2]. In Vivo: PTC-209 (60 mg/kg body weight; subcutaneously; once a day for 11 days) significantly reduces tumor volume[1]. |
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