Network Version
(E/Z)-Zotiraciclib Data Sheet
| Product Name: | (E/Z)-Zotiraciclib |
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|---|---|---|
| CAS No.: | 937270-47-8 | |
| Cat. No.: | HY-15166 | |
| MWt: | 372.46 | |
| Formula: | C23H24N4O | |
| Purity : | >98% | |
| Solubility: | DMSO : 26.5 mg/mL (71.15 mM; Need ultrasonic and warming) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| (E/Z)-Zotiraciclib ((E/Z)-TG02) is a potent inhibitor of CDK2, JAK2 and FLT3 with IC50s of 13, 73 and 56 nM, respectively. (E/Z)-Zotiraciclib effectively inhibits the proliferation of cancer cells, it can be used for the research of cancer[1][2]. IC50 & Target:IC50: 13 nM (CDK2), 73 nM (JAK2), 56 nM (FLT3)[1] In Vitro:(E/Z)-Zotiraciclib (0-10 μM) shows potent inhibition to CDK2, JAK2 and FLT3 with IC50s of 13, 73 and 56 nM, respectively[1]. (E/Z)-Zotiraciclib (0-10 μM; 48 h) inhibits proliferation of cancer cells[1]. (E/Z)-Zotiraciclib (8-1000 nM; 24 h) potently inhibits the CDK2 biomarker pRb in HCT-116 cells and potently againsts pRb in MV4-11 cells with an IC50 value of 0.13 μM[1]. In Vivo:(E/Z)-Zotiraciclib (50 and 75 mg/kg; p.o. once daily for 3 weeks) inhibits tumor growth[1]. (E/Z)-Zotiraciclib (15 and 75 mg/kg; p.o. once daily 2 days on and 5 days off; i.p. once daily 5 days on 5 days off) inhibits tumor growth in two manners[1]. | ||
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