Network Version
Torin 1 Data Sheet
| Product Name: | Torin 1 |
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|---|---|---|
| CAS No.: | 1222998-36-8 | |
| Cat. No.: | HY-13003 | |
| MWt: | 607.62 | |
| Formula: | C35H28F3N5O2 | |
| Purity : | >98% | |
| Solubility: | DMSO : 2 mg/mL (3.29 mM; ultrasonic and warming and heat to 60°C) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| Torin 1 is a potent inhibitor of mTOR with an IC50 of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC50 values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy. IC50 & Target: IC50: 2-10 nM (mTORC1), 2-10 nM (mTORC2), 3 nM (mTOR), 0.6 μM (ATM), 1 μM (DNA-PK), 1.8 μM (PI3K-α), 3 μM (hVPS34)[2] In Vitro: Torin1 (250 nM) completely inhibits proliferation and causes a G1/S cell cycle arrest, and decreases cell size to a greater degree than 50 nM rapamycin in wild-type MEFs[1]. Torin1 has more than 800-fold selectivity between mTOR and PI3Kis, and is very selective relative to other PIKK family kinases with the exception of DNA-PK[2]. In Vivo: Torin1 (20 mg/kg, i.p.) is efficacious in a U87MG xenograft model, and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues[2]. | ||
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