Network Version
Product Name: | JNK-IN-7 | |
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CAS No.: | 1408064-71-0 | |
Cat. No.: | HY-15617 | |
MWt: | 493.56 | |
Formula: | C28H27N7O2 | |
Purity : | >98% | |
Solubility: | DMSO : 33.33 mg/mL (ultrasonic);H<sub>2</sub>O : < 0.1 mg/mL | |
Mechanisms: | Target: Cancer | |
Biological Activity: | ||
JNK-IN-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively. IC50 & Target: IC50: 1.5 nM (JNK1), 2 nM (JNK2), 0.7 nM (JNK3)[1] In Vitro: JNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1(IC50=14.1 nM), YSK4 (IC50=4.8 nM), ERK3 (IC50=22 nM), PIK3C3, PIP5K3 and PIP4K2C[1]. Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function[2]. |
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