2. GPCR/G Protein Metabolic Enzyme/Protease Autophagy Apoptosis
  3. Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis
  4. Dinoprost

Dinoprost  (Synonyms: Prostaglandin F2α; PGF2α)

Cat. No.: HY-12956 Purity: ≥98.0%
COA Handling Instructions

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Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour.

For research use only. We do not sell to patients.

Dinoprost Chemical Structure

Dinoprost Chemical Structure

CAS No. : 551-11-1

Size Price Stock Quantity
Solid or liquid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid or liquid
5 mg USD 60 In-stock
10 mg USD 90 In-stock
25 mg USD 180 In-stock
50 mg USD 280 In-stock
100 mg USD 440 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Dinoprost:

Dinoprost Related Antibodies

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  • Purity & Documentation

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Description

Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].

IC50 & Target[1][2]

FP Receptor

 

Human Endogenous Metabolite

 

In Vitro

Dinoprost (Prostaglandin F2α; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells[1].
? Dinoprost (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dinoprost Related Antibodies

Apoptosis Analysis[1]

Cell Line: Goat luteal cells
Concentration: 1 μM
Incubation Time: For 24 hours
Result: Significantly increased the apoptotic rate (15.62±3.12%).

Cell Autophagy Assay[1]

Cell Line: Goat luteal cells
Concentration: 1 μM
Incubation Time: For 24 hours
Result: There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells.

Western Blot Analysis[1]

Cell Line: Goat luteal cells
Concentration: 1 μM
Incubation Time: For 24 hours
Result: The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.
Clinical Trial
Molecular Weight

354.48

Formula

C20H34O5
CAS No.
Appearance

<25°C Solid,>35°C Liquid

Color

White to light brown

SMILES

CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (282.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (282.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8210 mL 14.1052 mL 28.2103 mL
5 mM 0.5642 mL 2.8210 mL 5.6421 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.06%

COA (252 KB) HNMR (283 KB) RP-HPLC (210 KB) MS (175 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.8210 mL 14.1052 mL 28.2103 mL 70.5258 mL
5 mM 0.5642 mL 2.8210 mL 5.6421 mL 14.1052 mL
10 mM 0.2821 mL 1.4105 mL 2.8210 mL 7.0526 mL
15 mM 0.1881 mL 0.9403 mL 1.8807 mL 4.7017 mL
20 mM 0.1411 mL 0.7053 mL 1.4105 mL 3.5263 mL
25 mM 0.1128 mL 0.5642 mL 1.1284 mL 2.8210 mL
30 mM 0.0940 mL 0.4702 mL 0.9403 mL 2.3509 mL
40 mM 0.0705 mL 0.3526 mL 0.7053 mL 1.7631 mL
50 mM 0.0564 mL 0.2821 mL 0.5642 mL 1.4105 mL
60 mM 0.0470 mL 0.2351 mL 0.4702 mL 1.1754 mL
80 mM 0.0353 mL 0.1763 mL 0.3526 mL 0.8816 mL
100 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.7053 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dinoprost Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dinoprost551-11-1Prostaglandin F2α PGF2αProstaglandin ReceptorEndogenous MetaboliteAutophagyApoptosisluteolytichormoneluminalepitheliumcorpusluteumlabourERstressInhibitorinhibitorinhibit

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