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Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.

For research use only. We do not sell to patients.

Dixyrazine Chemical Structure

Dixyrazine Chemical Structure

CAS No. : 2470-73-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 470 In-stock
Solution
10 mM * 1 mL in DMSO USD 470 In-stock
Solid
1 mg USD 240 In-stock
5 mg USD 500 In-stock
10 mg USD 800 In-stock
20 mg USD 1200 In-stock
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Description

Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.

In Vivo

Pretreatment with Dixyrazine 10 mg/kg completely prevents the brain oedema and significantly reduces the albumin increase in cerebrospinal fluid (CSF)[1]. The phenothiazine Dixyrazine (5 mg/kg i.v.) has minimal, transient hypotensive effects but significantly reduces the leakage of 126I labelled serum albumin in conscious rats subjected to acute hypertension provoked by i.v. Adrenaline or Bicuculline. The diameters of pial arteries and veins are continuously measured with a multichannel videoangiometer through a closed cranial window in anesthetized rats before and after i.v. injection of Dixyrazine (5 mg/kg). Dixyrazine, 5 mg /kg, induces a slight transitory decrease in blood pressure (10-20 mm Hg). Maximum MAP is slightly but not significantly lower in Dixyrazine-treated rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

427.60

Formula

C24H33N3O2S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(CN1C2=C(C=CC=C2)SC3=CC=CC=C13)CN4CCN(CCOCCO)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (233.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3386 mL 11.6932 mL 23.3863 mL
5 mM 0.4677 mL 2.3386 mL 4.6773 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.87%

References
Animal Administration
[2]

Rats[2]
Male Sprague-Dawley rats (200-225 g) are used. Evans blue and 125I-HSA are used as tracers, and controls are compared to rats pretreated with Dixyrazine 5 mL/kg or 15 mg/kg. The lower dose is given 15-20 min before the infusion of urea (that is the same interval as in the hypertension experiments). Because of larger effects on blood pressure with higher doses, the interval has to be extended to 40 min in this group. The radioactivity is determined in the right and left hemisphere and related to the activity in the blood.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3386 mL 11.6932 mL 23.3863 mL 58.4659 mL
5 mM 0.4677 mL 2.3386 mL 4.6773 mL 11.6932 mL
10 mM 0.2339 mL 1.1693 mL 2.3386 mL 5.8466 mL
15 mM 0.1559 mL 0.7795 mL 1.5591 mL 3.8977 mL
20 mM 0.1169 mL 0.5847 mL 1.1693 mL 2.9233 mL
25 mM 0.0935 mL 0.4677 mL 0.9355 mL 2.3386 mL
30 mM 0.0780 mL 0.3898 mL 0.7795 mL 1.9489 mL
40 mM 0.0585 mL 0.2923 mL 0.5847 mL 1.4616 mL
50 mM 0.0468 mL 0.2339 mL 0.4677 mL 1.1693 mL
60 mM 0.0390 mL 0.1949 mL 0.3898 mL 0.9744 mL
80 mM 0.0292 mL 0.1462 mL 0.2923 mL 0.7308 mL
100 mM 0.0234 mL 0.1169 mL 0.2339 mL 0.5847 mL
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Dixyrazine
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