2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-PEG3-NH2 hydrochloride

(S,R,S)-AHPC-PEG3-NH2 hydrochloride  (Synonyms: VH032-PEG3-NH2 hydrochloride; VHL Ligand-Linker Conjugates 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 5)

Cat. No.: HY-103602 Purity: 98.20%
COA Handling Instructions

Molarity Calculator

(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG3-NH2 hydrochloride Chemical Structure

(S,R,S)-AHPC-PEG3-NH2 hydrochloride Chemical Structure

CAS No. : 2097971-11-2

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Based on 1 publication(s) in Google Scholar

Other Forms of (S,R,S)-AHPC-PEG3-NH2 hydrochloride:

(S,R,S)-AHPC-PEG3-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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  • Purity & Documentation

  • References

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Description

(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

IC50 & Target

VHL

 

Molecular Weight

656.23

Formula

C30H46ClN5O7S
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light, stored under nitrogen
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (304.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5239 mL 7.6193 mL 15.2386 mL
5 mM 0.3048 mL 1.5239 mL 3.0477 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (76.19 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.20%

COA (250 KB) HNMR (173 KB) LCMS (106 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5239 mL 7.6193 mL 15.2386 mL 38.0964 mL
5 mM 0.3048 mL 1.5239 mL 3.0477 mL 7.6193 mL
10 mM 0.1524 mL 0.7619 mL 1.5239 mL 3.8096 mL
15 mM 0.1016 mL 0.5080 mL 1.0159 mL 2.5398 mL
20 mM 0.0762 mL 0.3810 mL 0.7619 mL 1.9048 mL
25 mM 0.0610 mL 0.3048 mL 0.6095 mL 1.5239 mL
30 mM 0.0508 mL 0.2540 mL 0.5080 mL 1.2699 mL
40 mM 0.0381 mL 0.1905 mL 0.3810 mL 0.9524 mL
50 mM 0.0305 mL 0.1524 mL 0.3048 mL 0.7619 mL
60 mM 0.0254 mL 0.1270 mL 0.2540 mL 0.6349 mL
80 mM 0.0190 mL 0.0952 mL 0.1905 mL 0.4762 mL
100 mM 0.0152 mL 0.0762 mL 0.1524 mL 0.3810 mL
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(S,R,S)-AHPC-PEG3-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG3-NH22097971-11-2VH032-PEG3-NH2VHL Ligand-Linker Conjugates 1 E3 ligase Ligand-Linker Conjugates 5E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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