1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor

F 11440 (Synonyms: Eptapirone free base)

Cat. No.: HY-19946 Purity: 99.80%
Data Sheet SDS Handling Instructions

F 11440 is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.

For research use only. We do not sell to patients.
F 11440 Chemical Structure

F 11440 Chemical Structure

CAS No. : 179756-58-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 319 In-stock
1 mg USD 180 In-stock
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg USD 2520 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

F 11440 is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. Target: 5-HT1A The affinity of F 11440 for 5-HT1Abinding sites (pKi, 8.33) was higher than that of buspirone (pKi , 7.50), and somewhat lower than that of flesinoxan (pKi , 8.91).In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels, respectively). F 11440, shown here to be a potent, selective, high efficacy 5-HT1Areceptor agonist, appears to have the potential to exert marked anxiolytic and antidepressant activity in humans.[1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.8952 mL 14.4760 mL 28.9519 mL
5 mM 0.5790 mL 2.8952 mL 5.7904 mL
10 mM 0.2895 mL 1.4476 mL 2.8952 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

345.4

Formula

C₁₆H₂₃N₇O₂

CAS No.

179756-58-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 6 mg/mL (Need ultrasonic)

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
F 11440
Cat. No.:
HY-19946
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