FKK

Cat. No.: HY-100194: FAQs
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FKK is an indazole derivative and also a novel bronchodilator.

For research use only. We do not sell to patients.

FKK Chemical Structure

CAS No. : 78299-79-3

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Description	FKK is an indazole derivative and also a novel bronchodilator.
In Vivo	FKK is an indazole derivative and also a novel bronchodilator. FKK (0.1 to 3.0 mg/kg, i.v.) slightly increases respiratory frequency, left ventricular (LV) dp/dt max and myocardial contractile force. A slight increase followed by a decrease is observed in systemic blood pressure and LV systolic pressure. FKK causes direct vasodilation in the coronary, mesenteric and femoral vasculatures, but has no effect on the renal vasculature. It is particularly pertinent that FKK (30 mg/kg, i.d., enough to cause marked bronchodilation), unlike aminophylline (30 mg/kg, i.d.), does not significantly influence the cardiovascular system^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	329.23
Formula	C₁₇H₁₇BrN₂
CAS No.	78299-79-3
SMILES	CC1=CC2=C(C3=CC=CC=C3)N(CCC4)[N+]4=C2C=C1.[Br-]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. Shiraki Y, et al. Effects of an indazole derivative, FKK, a novel bronchodilator, on the cardiovascular system in dogs. Arch Int Pharmacodyn Ther. 1985 Jan;273(1):155-66. [Content Brief]

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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FKK78299-79-3OthersInhibitorinhibitorinhibit

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FKK

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