1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Fosphenytoin disodium

Fosphenytoin sodium is a phenytoin proagent with similar anticonvulsant properties. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.

For research use only. We do not sell to patients.

Fosphenytoin disodium Chemical Structure

Fosphenytoin disodium Chemical Structure

CAS No. : 92134-98-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 73 In-stock
Solution
10 mM * 1 mL in Water USD 73 In-stock
Solid
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10 mg USD 70 In-stock
50 mg USD 120 In-stock
100 mg USD 190 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Fosphenytoin disodium:

Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Fosphenytoin sodium is a phenytoin proagent with similar anticonvulsant properties. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.

In Vivo

Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed[1]. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

406.24

Formula

C16H13N2Na2O6P

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(COP(O[Na])(O[Na])=O)C(C(C2=CC=CC=C2)(C3=CC=CC=C3)N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (246.16 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4616 mL 12.3080 mL 24.6160 mL
5 mM 0.4923 mL 2.4616 mL 4.9232 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (61.54 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
Animal Administration
[1]

A total of four groups of rats, including normal (n=2), sham operated (n=2), ischemia with saline-treated (n=2), and ischemia with fosphenytoin-treated (n=2), are studied. Postischemic rats in saline-treated and fosphenytoin-treated groups receive a single i.m. injection of saline or fosphenytoin (30 mg/kg), respectively, in the right hind limb 5 minutes after resuscitation. Sham-operated animals are treated similarly except for chest compression. All rats are killed on the 7th postischemic day by decapitation. Brains are immediately removed, bisected longitudinally, and immersed in 4% buffered neutral formaldehyde containing 0.25% glutaraldehyde for a minimum of 2 days at 4°C. Portions of the brain containing the dorsal hippocampus are coronally sectioned with a vibratome at 40 μm. With the aid of a dissecting microscope, rectangular blocks of about 1 mm2 in size encompassing the mid-CA1 region from sections that approximate Bregma -3.6 are dissected, postfixed in 2% osmium tetroxide, and dehydrated in ascending concentrations of ethanol before being embedded in Araldite 502. Sections of polymerized blocks 1 μm thick are cut and toluidine blue stained for light microscopic examination.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.4616 mL 12.3080 mL 24.6160 mL 61.5400 mL
5 mM 0.4923 mL 2.4616 mL 4.9232 mL 12.3080 mL
10 mM 0.2462 mL 1.2308 mL 2.4616 mL 6.1540 mL
15 mM 0.1641 mL 0.8205 mL 1.6411 mL 4.1027 mL
20 mM 0.1231 mL 0.6154 mL 1.2308 mL 3.0770 mL
25 mM 0.0985 mL 0.4923 mL 0.9846 mL 2.4616 mL
30 mM 0.0821 mL 0.4103 mL 0.8205 mL 2.0513 mL
40 mM 0.0615 mL 0.3077 mL 0.6154 mL 1.5385 mL
50 mM 0.0492 mL 0.2462 mL 0.4923 mL 1.2308 mL
60 mM 0.0410 mL 0.2051 mL 0.4103 mL 1.0257 mL
80 mM 0.0308 mL 0.1538 mL 0.3077 mL 0.7692 mL
100 mM 0.0246 mL 0.1231 mL 0.2462 mL 0.6154 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Fosphenytoin disodium
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