1. Anti-infection
  2. Bacterial

Framycetin (Synonyms: Fradiomycin B; Neomycin B)

Cat. No.: HY-17624
Handling Instructions

Framycetin (Fradiomycin B; Neomycin B) is an aminoglycoside antibiotic. It inhibits hammerhead ribozyme with a Ki of 13.5 μM.

For research use only. We do not sell to patients.
Framycetin Chemical Structure

Framycetin Chemical Structure

CAS No. : 119-04-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO $68 In-stock
5 mg $50 In-stock
10 mg $70 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

Framycetin (Fradiomycin B; Neomycin B) is an aminoglycoside antibiotic. It inhibits hammerhead ribozyme with a Ki of 13.5 μM.

IC50 & Target

Ki: 13.5 μM (hammerhead ribozyme)[1]

In Vitro

Neomycin B is used clinically to treat hepatic encephalopathy (by reducing ammonium levels in the gut) and enteropathogenic Escherichia coli infections. Neomycin B targets the bacterial and human ribosome and affect translation. Addition of neomycin B, to an HCC cell line selectively inhibits production of the mature miRNA, boosts a downstream protein, and inhibits invasion[2]. Neomycin B interacts with various target RNAs that have no primary sequence homology. This means that the drug binds to a structural rather than a sequence motif of the RNA. Its primary cognate target is the decoding site of the 16S rRNA, but it also binds to the Rev-responsive element in HIV-1, group I introns, and the hammerhead ribozyme, and thus inhibits their biological function[3]. The aminoglycoside antibiotic neomycin B induces misreading of the genetic code during translation and inhibits several ribozymes. The ribosomal target site of neomycin B is the 16 S rRNA 1400 to 1500 region, which has been clearly demonstrated by dissecting this domain from a small RNA of 27 nucleotides. This small subdomain of the 16 S rRNA is protected from chemical modification by neomycin at the same positions as in the context of the 30 S subunit[4].

References
M.Wt

614.64

Formula

C₂₃H₄₆N₆O₁₃

CAS No.

119-04-0

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 60 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Framycetin
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HY-17624
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