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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

GW-1100

HY-50691

(GW1100; GW1100)

GW-1100

GW-1100 Chemical Structure

GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99.

Price and Availability of GW-1100

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Size Price Stock Quantity
10 mM * 1 mL $61 In-stock
5 mg $59 In-stock
10 mg $112 In-stock
50 mg $468 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL €60 In-stock
5 mg €58 In-stock
10 mg €110 In-stock
50 mg €459 In-stock
100 mg Get quote
200 mg Get quote

Discount Prices Available for Larger Orders.

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GW-1100 Data Sheet

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    Purity: 98.13%

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    DataSheet

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Related Compound Libraries

Inhibitor Kit

Biological Activity of GW-1100

GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99.
IC50 value:
Target: GPR40
GPR40 is a G protein-coupled receptor (GPCR) that is activated by saturated and unsaturated long chain fatty acids. It is thought to play a role in the potentiation of insulin secretion by fatty acids in a glucose-sensitive manner. GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99. However at concentrations up to 10 μM, GW 1100 has no effect on GPR120-mediated stimulation of intracellular Ca2+ release induced by either GW 9508 or linoleic acid. In the MIN6 mouse insulinoma cell line, 1 μM GW 1100 inhibits the potentiating effects of GW 9508 and linoleic acid on glucose-stimulated insulin secretion.

Chemical Information

M.Wt 520.58 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C27H25FN4O4S
CAS No 306974-70-9
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.9209 mL 9.6047 mL 19.2093 mL
5 mM 0.3842 mL 1.9209 mL 3.8419 mL
10 mM 0.1921 mL 0.9605 mL 1.9209 mL

References on GW-1100

  • Related GPR40 Products

  • GPR40 Activator 1

    GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes.

  • GPR40 Activator 2

    GPR40 Activator 2 is a potent GPR40 activator from patents WO 2012147516 A1, WO 2012046869A1 and WO 2011078371 A1.

  • GW9508

    GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.

  • TAK-875

    TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 0.072 _mu_M.

  • TUG-770

    TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC50 of 6 nM for hFFA1.