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Pareptide monohydrochloride is a melanotropin-inhibiting factor (MIF) metabolically stable analogue.

For research use only. We do not sell to patients.

Pareptide monohydrochloride Chemical Structure

Pareptide monohydrochloride Chemical Structure

CAS No. : 63236-23-7

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Description

Pareptide monohydrochloride is a melanotropin-inhibiting factor (MIF) metabolically stable analogue.

In Vivo

Chronic coadministration of Pareptide (0.25 mg/kg, SC, BID, 3.5 days) to mice pretreated with Haloperidol (8.0 mg/kg, IP, BID, 3 days) significantly increases the cataleptic effects of a smaller challenge dose of Haloperidol (2.0 mg/kg, IP) given 15 hours after the last pretreatment injections (p<0.01)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

334.84

Formula

C14H27ClN4O3

CAS No.
SMILES

O=C([C@@H]1CCCN1)N(C)[C@H](CC(C)C)C(NCC(N)=O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
Animal Administration
[1]

Mice[1]
Male albino mice of a Swiss-Webster derived strain and eighing from 26-34 g are used. Single doses of MIF-I (0.03-2.0 mg/kg, SC) and chronic pretreatments with MIF-I (0,03-2.0 mg/kg, SC, BID, 3.5 days) or Pareptide (0.25 mg/kg, SC, BID, 3.5 days) do not affect the acute cataleptic response to Haloperidol in the mouse. Pareptide is given SC in a 5 mL/kg injection volume. Chronic pretreatment with Haloperidol (8.0 mg/kg, IP, BID, 3 days) decreases the duration of catalepsy in mice given smaller challenge doses of Haloperidol (2.0 or 3.0 mg/kg, IP) 15 hours after the last pretreatment injections. Administration of either MIF-I or Pareptide to mice also chronically pretreated with Haloperidol antagonizes the development of tolerance[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Pareptide monohydrochloride Related Classifications

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Pareptide monohydrochloride
Cat. No.:
HY-U00271
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