2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Glycopyrrolate

Glycopyrrolate  (Synonyms: Glycopyrronium bromide; Glycopyrrolate bromide)

Cat. No.: HY-17465 Purity: 99.88%
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Glycopyrrolate (Glycopyrronium bromide), a quaternary ammonium derivative, is a muscarinic receptor antagonist. Glycopyrrolate has bronchoprotective effect and produces a beneficial effect on blood pressure. Glycopyrrolate can be used for the research of bronchial diseases.

For research use only. We do not sell to patients.

Glycopyrrolate Chemical Structure

Glycopyrrolate Chemical Structure

CAS No. : 596-51-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Glycopyrrolate:

Glycopyrrolate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Glycopyrrolate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Glycopyrrolate (Glycopyrronium bromide), a quaternary ammonium derivative, is a muscarinic receptor antagonist. Glycopyrrolate has bronchoprotective effect and produces a beneficial effect on blood pressure. Glycopyrrolate can be used for the research of bronchial diseases[1][2][3].

In Vitro

Glycopyrrolate (1-10 nM, 30 min) has an effect of protecting large and small airways in guinea pig lung slices[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycopyrrolate Related Antibodies
In Vivo

Glycopyrrolate (0.005-0.01 mg/kg, Intravenous injection, single dose or give a second dose if heart rate (HR) < 70 beats/min ) produces a beneficial effect on blood pressure in anesthetized dogs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anesthetized dogs[2]
Dosage: 0.005mg/kg, 0.01 mg/kg
Administration: Intravenous injection (i.v.)
Result: Resulted in a significant increase in HR.
Significant increased systolic, diastolic, and mean BP above baseline values.
Clinical Trial
Molecular Weight

398.33

Formula

C19H28BrNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[N+]1(C)CC(OC(C(O)(C2CCCC2)C3=CC=CC=C3)=O)CC1.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (251.05 mM; Need ultrasonic)

DMSO : 100 mg/mL (251.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5105 mL 12.5524 mL 25.1048 mL
5 mM 0.5021 mL 2.5105 mL 5.0210 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.28 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.28 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (125.52 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.88%

COA (255 KB) LCMS (264 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.5105 mL 12.5524 mL 25.1048 mL 62.7620 mL
5 mM 0.5021 mL 2.5105 mL 5.0210 mL 12.5524 mL
10 mM 0.2510 mL 1.2552 mL 2.5105 mL 6.2762 mL
15 mM 0.1674 mL 0.8368 mL 1.6737 mL 4.1841 mL
20 mM 0.1255 mL 0.6276 mL 1.2552 mL 3.1381 mL
25 mM 0.1004 mL 0.5021 mL 1.0042 mL 2.5105 mL
30 mM 0.0837 mL 0.4184 mL 0.8368 mL 2.0921 mL
40 mM 0.0628 mL 0.3138 mL 0.6276 mL 1.5691 mL
50 mM 0.0502 mL 0.2510 mL 0.5021 mL 1.2552 mL
60 mM 0.0418 mL 0.2092 mL 0.4184 mL 1.0460 mL
80 mM 0.0314 mL 0.1569 mL 0.3138 mL 0.7845 mL
100 mM 0.0251 mL 0.1255 mL 0.2510 mL 0.6276 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Glycopyrrolate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycopyrrolate596-51-0GlycopyrroniummAChRMuscarinic acetylcholine receptorChronic obstructive pulmonary diseaseAnesthetized dogsAnticholinergicInhibitorinhibitorinhibit

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