2. GPCR/G Protein Apoptosis
  3. GnRH Receptor Apoptosis
  4. Goserelin

Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Goserelin Chemical Structure

Goserelin Chemical Structure

CAS No. : 65807-02-5

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Goserelin Related Antibodies

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Description

Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer[1][2].

IC50 & Target

GnRH[1]
In Vitro

Goserelin (1 nM-1 mM; 48-72 hours) promots EOC cell apoptosis[1].
Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells[1].
Goserelin (100 μM; 24-72 hours) influences EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Goserelin Related Antibodies

Apoptosis Analysis[1]

Cell Line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
Concentration: 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM
Incubation Time: 48 hours, 72 hours
Result: Significantly increased the total apoptosis rate of SKOV3-ip, SKOV3 and A2780 cells.

Western Blot Analysis[1]

Cell Line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
Concentration: 1 nM, 10 nM, 100 nM, 1μM , 10 μM, 100 μM, 1 mM
Incubation Time: 48 hours, 72 hours
Result: The expression of cleaved-caspase-3 and cleaved-PARP were observably increased at 100 μM.

RT-PCR[1]

Cell Line: SKOV3-ip cells
Concentration: 100 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Expression of human apoptosis-related genes regulated
In Vivo

Goserelin (100 µg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old specific-pathogen free (SPF) female nude mice (18-20 g), subcutaneous xenograft tumor model[1]
Dosage: 100 µg/mice
Administration: Subcutaneous injection, daily, for 19 days
Result: Significantly increased the proportion of apoptotic cells in the subcutaneous xenograft tumors
Clinical Trial
Molecular Weight

1269.41

Formula

C59H84N18O14
CAS No.
Shipping

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Storage

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Purity & Documentation
References
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Goserelin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Goserelin65807-02-5ICI 118630ICI118630ICI-118630GnRH ReceptorApoptosisGonadotropin releasing hormone receptorGNRHRgonadotropin-releasinghormoneGnRHagonistepithelialovariancancerapoptosisbreastprostateanti-hormonalInhibitorinhibitorinhibit

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