Homatropine methylbromide (Synonyms: Homatropine methobromide)

Name: Homatropine methylbromide
Brand: MedChemExpress
SKU: HY-B1388
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1388 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC₅₀ of 162.

For research use only. We do not sell to patients.

Homatropine methylbromide Chemical Structure

CAS No. : 80-49-9

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10 mM * 1 mL in DMSO ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 72	In-stock	Estimated Time of Arrival: December 31
200 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Homatropine methylbromide:

Homatropine Bromide In-stock
Homatropine Get quote

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Description

Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC₅₀ of 162.5 nM and 170.3 nM, respectively.

IC₅₀ & Target

IC50: WKY-E (162.5 nM), SHR-E (170.4 nM)

In Vitro

Homatropine methylbromide (Homatropine methobromide) (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine methylbromide (Homatropine methobromide) (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pre-treatment with Homatropine methylbromide (Homatropine methobromide) (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

370.28

Formula

C₁₇H₂₄BrNO₃

CAS No.

80-49-9

Appearance

Solid

Color

White to off-white

SMILES

C[N+]1([C@@H]2C[C@@H](OC(C(O)C3=CC=CC=C3)=O)C[C@H]1CC2)C.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (270.07 mM)

DMSO : ≥ 31 mg/mL (83.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7007 mL	13.5033 mL	27.0066 mL
5 mM	0.5401 mL	2.7007 mL	5.4013 mL
10 mM	0.2701 mL	1.3503 mL	2.7007 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (276 KB) SDS (392 KB)

COA (253 KB) HNMR (306 KB)

Handling Instructions (2659 KB)

References

[1]. Sim MK et al. Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study. Clin Exp Hypertens. 1993 Mar;15(2):409-21. [Content Brief]

[2]. Bryant SM et al. Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. J Med Toxicol. 2006 Dec;2(4):156-9. [Content Brief]

[3]. Leung E et al. Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig. Eur J Pharmacol. 1982 May 7;80(1):11-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.7007 mL	13.5033 mL	27.0066 mL	67.5165 mL
	5 mM	0.5401 mL	2.7007 mL	5.4013 mL	13.5033 mL
	10 mM	0.2701 mL	1.3503 mL	2.7007 mL	6.7516 mL
	15 mM	0.1800 mL	0.9002 mL	1.8004 mL	4.5011 mL
	20 mM	0.1350 mL	0.6752 mL	1.3503 mL	3.3758 mL
	25 mM	0.1080 mL	0.5401 mL	1.0803 mL	2.7007 mL
	30 mM	0.0900 mL	0.4501 mL	0.9002 mL	2.2505 mL
	40 mM	0.0675 mL	0.3376 mL	0.6752 mL	1.6879 mL
	50 mM	0.0540 mL	0.2701 mL	0.5401 mL	1.3503 mL
	60 mM	0.0450 mL	0.2251 mL	0.4501 mL	1.1253 mL
	80 mM	0.0338 mL	0.1688 mL	0.3376 mL	0.8440 mL
H₂O	100 mM	0.0270 mL	0.1350 mL	0.2701 mL	0.6752 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Homatropine methylbromide Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Homatropine methylbromide80-49-9Homatropine methobromidemAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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Homatropine methylbromide (Synonyms: Homatropine methobromide)

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Other Forms of Homatropine methylbromide:

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Homatropine methylbromide Related Antibodies

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Complete Stock Solution Preparation Table

Homatropine methylbromide Related Classifications

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