IFN alpha-IFNAR-IN-1

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IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (IFN alpha-IFNAR-IN-1 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

IFN alpha-IFNAR-IN-1 Chemical Structure

CAS No. : 844882-93-5

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Other In-stock Forms of IFN alpha-IFNAR-IN-1:

IFN alpha-IFNAR-IN-1 hydrochloride

Other Forms of IFN alpha-IFNAR-IN-1:

IFN alpha-IFNAR-IN-1 hydrochloride In-stock

19 Publications Citing Use of MCE IFN alpha-IFNAR-IN-1

: IFN alpha-IFNAR-IN-1 purchased from MedChemExpress. Usage Cited in: Sci Rep. 2016 Jul 14;6:29665. [Abstract]; PAMs are first pretreated with IFN-alpha-IFNAR-IN-1 or mock pretreated with medium containing DMSO for 2 h. The cells are then infected with the HP-PRRSV virus at an MOI of 5 or mock-infected with DMEM for 12 h and 16 h, respectively. The cell lysates are collected and analyzed by western blot. The fold change of SAMHD1 protein is expressed as densitometric units of the band normalized to the β-actin level relative to the uninfected control. The error bar represents standard deviation from three

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Description	IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM). IC50 value: Target: IFN alpha-IFNAR interaction inhibitor IFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1].
Molecular Weight	279.40
Formula	C₁₈H₁₇NS
CAS No.	844882-93-5
SMILES	CNCC1=CC=CC=C1SC2=C(C=CC=C3)C3=CC=C2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61. [Content Brief]