2. NF-κB
  3. IKK
  4. TBK1/IKKε-IN-2

TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.

For research use only. We do not sell to patients.

TBK1/IKKε-IN-2 Chemical Structure

TBK1/IKKε-IN-2 Chemical Structure

CAS No. : 1292310-49-6

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10 mM * 1 mL in DMSO
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Customer Review

Based on 2 publication(s) in Google Scholar

TBK1/IKKε-IN-2 Related Antibodies

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IKK-α IKK-β IKK IKKε TBK1

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.

IC50 & Target[1]

TBK1

0.6 nM (IC50, at 5 μM ATP)

IKKε

3.9 nM (IC50, at 10 μM ATP)

In Vitro

TBK1/IKKε-IN-2 (Cmpound #1) inhibits TBK1 biochemical function in Ulight kinase assay at 5 and 250 μM ATP concentration with IC50s of 0.6 and 2.6 nM, rsespectively. TBK1/IKKε-IN-2 inhibits IKKε biochemical function in Ulight kinase assay at 10 μM ATP with an IC50 of 3.9 nM. The IC50 of TBK1/IKKε-IN-2 in the Panc 02.13 proliferation assay is 5 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TBK1/IKKε-IN-2 Related Antibodies
Molecular Weight

457.52

Formula

C26H27N5O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=CC(C2=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC=C2)=CC=C1OC5CCOCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 21.5 mg/mL (46.99 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1857 mL 10.9285 mL 21.8570 mL
5 mM 0.4371 mL 2.1857 mL 4.3714 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Cell Assay
[1]

Cell proliferation experiments are carried out in a 96-well format (6 replicates), Panc 02.13 cells are plated at a density of 2,000 to 5,000 cells per well. At 24 hours following cell seeding, the cells are treated with the tool inhibitor titrations (e.g., TBK1/IKKε-IN-2, 1 nM, 10 nM, 100 nM, 1 μM and 10 μM) for 4 days at 37°C and then assayed by using the ATP CellTiter-Glo luminescent cell viability assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1857 mL 10.9285 mL 21.8570 mL 54.6424 mL
5 mM 0.4371 mL 2.1857 mL 4.3714 mL 10.9285 mL
10 mM 0.2186 mL 1.0928 mL 2.1857 mL 5.4642 mL
15 mM 0.1457 mL 0.7286 mL 1.4571 mL 3.6428 mL
20 mM 0.1093 mL 0.5464 mL 1.0928 mL 2.7321 mL
25 mM 0.0874 mL 0.4371 mL 0.8743 mL 2.1857 mL
30 mM 0.0729 mL 0.3643 mL 0.7286 mL 1.8214 mL
40 mM 0.0546 mL 0.2732 mL 0.5464 mL 1.3661 mL
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TBK1/IKKε-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TBK1/IKKε-IN-21292310-49-6IKKIκB kinaseI kappa B kinaseInhibitorinhibitorinhibit

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