2. Membrane Transporter/Ion Channel
  3. CRM1
  4. Eltanexor Z-isomer

Eltanexor Z-isomer  (Synonyms: KPT-8602 (Z-isomer))

Cat. No.: HY-100423A Purity: 96.59%
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Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602.

For research use only. We do not sell to patients.

Eltanexor Z-isomer Chemical Structure

Eltanexor Z-isomer Chemical Structure

CAS No. : 1642300-78-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 328 In-stock
Solution
10 mM * 1 mL in DMSO USD 328 In-stock
Solid
1 mg USD 168 In-stock
5 mg USD 348 In-stock
10 mg USD 468 In-stock
50 mg USD 1380 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Eltanexor Z-isomer:

Eltanexor Z-isomer Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Eltanexor Z-isomer

Proliferation Assay

    Eltanexor Z-isomer purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Feb 13;160:114402.  [Abstract]

    A combination of sorafenib and KPT-8602 (30 mg/kg/day; 27 days) has a better tumor inhibition effect than sorafenib alone in xenograft tumor mice model (Fig. A-C).

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor. IC50： In Vitro: Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively[1]. In Vivo:

    Molecular Weight

    428.29

    Formula

    C17H10F6N6O
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(N)/C(C1=CN=CN=C1)=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (116.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3349 mL 11.6743 mL 23.3487 mL
    5 mM 0.4670 mL 2.3349 mL 4.6697 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.75 mg/mL (6.42 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3349 mL 11.6743 mL 23.3487 mL 58.3717 mL
    5 mM 0.4670 mL 2.3349 mL 4.6697 mL 11.6743 mL
    10 mM 0.2335 mL 1.1674 mL 2.3349 mL 5.8372 mL
    15 mM 0.1557 mL 0.7783 mL 1.5566 mL 3.8914 mL
    20 mM 0.1167 mL 0.5837 mL 1.1674 mL 2.9186 mL
    25 mM 0.0934 mL 0.4670 mL 0.9339 mL 2.3349 mL
    30 mM 0.0778 mL 0.3891 mL 0.7783 mL 1.9457 mL
    40 mM 0.0584 mL 0.2919 mL 0.5837 mL 1.4593 mL
    50 mM 0.0467 mL 0.2335 mL 0.4670 mL 1.1674 mL
    60 mM 0.0389 mL 0.1946 mL 0.3891 mL 0.9729 mL
    80 mM 0.0292 mL 0.1459 mL 0.2919 mL 0.7296 mL
    100 mM 0.0233 mL 0.1167 mL 0.2335 mL 0.5837 mL
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    Eltanexor Z-isomer Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Eltanexor Z-isomer1642300-78-4KPT-8602 (Z-isomer)CRM1Chromosomal Maintenance 1Exportin 1XPO1Inhibitorinhibitorinhibit

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