2. Epigenetics
  3. Histone Methyltransferase
  4. MM-102

MM-102  (Synonyms: HMTase Inhibitor IX)

Cat. No.: HY-12220 Purity: 99.17%
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MM-102 (HMTase Inhibitor IX) is a potent WDR5/MLL interaction inhibitor, achieves IC50= 2.

For research use only. We do not sell to patients.

MM-102 Chemical Structure

MM-102 Chemical Structure

CAS No. : 1417329-24-8

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5 mg USD 132 In-stock
10 mg USD 216 In-stock
50 mg USD 912 In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of MM-102:

MM-102 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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  • Purity & Documentation

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  • Customer Review

Description

MM-102 (HMTase Inhibitor IX) is a potent WDR5/MLL interaction inhibitor, achieves IC50= 2.4 nM with an estimated Ki< 1 nM in WDR5 binding assay, which is >200 times more potent than the ARA peptide. IC50 value: 2.4 nM Target: MLL in vitro: MM-102 inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins. MM-102, with the highest binding affinities to WDR5, also show the most potent inhibitory activity in the HMT assay with IC50 = 0.4-0.9 μM. MM-102 dose-dependently inhibits cell growth in the MV4;11 and KOPN8 leukemia cell lines, which carry MLL1-AF4 and MLL1-ENL fusion proteins, respectively. MM-102 has IC50 = 25 μM in both cell lines and completely inhibits cell growth in these cell lines at 75 μM. MM-102 effectively and selectively inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins and has minimal effect in leukemia cells with wild-type MLL1 protein.[1]

Molecular Weight

669.80

Formula

C35H49F2N7O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(NC([C@@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCCNC(N)=N)=O)CCCC1)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (186.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4930 mL 7.4649 mL 14.9298 mL
5 mM 0.2986 mL 1.4930 mL 2.9860 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4930 mL 7.4649 mL 14.9298 mL 37.3246 mL
5 mM 0.2986 mL 1.4930 mL 2.9860 mL 7.4649 mL
10 mM 0.1493 mL 0.7465 mL 1.4930 mL 3.7325 mL
15 mM 0.0995 mL 0.4977 mL 0.9953 mL 2.4883 mL
20 mM 0.0746 mL 0.3732 mL 0.7465 mL 1.8662 mL
25 mM 0.0597 mL 0.2986 mL 0.5972 mL 1.4930 mL
30 mM 0.0498 mL 0.2488 mL 0.4977 mL 1.2442 mL
40 mM 0.0373 mL 0.1866 mL 0.3732 mL 0.9331 mL
50 mM 0.0299 mL 0.1493 mL 0.2986 mL 0.7465 mL
60 mM 0.0249 mL 0.1244 mL 0.2488 mL 0.6221 mL
80 mM 0.0187 mL 0.0933 mL 0.1866 mL 0.4666 mL
100 mM 0.0149 mL 0.0746 mL 0.1493 mL 0.3732 mL
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MM-102 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM-1021417329-24-8HMTase Inhibitor IXMM102MM 102Histone MethyltransferaseInhibitorinhibitorinhibit

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