MTEP hydrochloride

Name: MTEP hydrochloride
Brand: MedChemExpress
SKU: HY-13206
Rating: 4.5 (2 reviews)

Cat. No.: HY-13206 Purity: 99.81%: FAQs
Data Sheet SDS COA Handling Instructions

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MTEP hydrochloride is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC₅₀ of 5 nM and a K_i of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects. MTEP hydrochloride can be used for Parkinson's disease research.

For research use only. We do not sell to patients.

MTEP hydrochloride Chemical Structure

CAS No. : 1186195-60-7

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 123	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 123	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 72	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 112	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 504	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of MTEP hydrochloride:

MTEP Get quote

2 Publications Citing Use of MCE MTEP hydrochloride

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•Related Screening Libraries:

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

mGluR5

5 nM (IC₅₀)

mGluR5

16 nM (Ki)

In Vitro

MTEP shows highly selective for mGluR5 over mGluR1, has no effect on other mGluR subtypes, and has fewer off-target effects than MPEP (HY-14609A)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MTEP (0-5 mg/kg, i.p., once) inhibits the catalepsy induced by Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.)^[2].
MTEP (0.3-3 mg/kg, intraperitoneal injection, once) induces antidepressant-like effects in male C57BL/6J mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (215-315 g, 5-9/group)^[2]
Dosage:	1, 3 and 5 mg/kg
Administration:	IP, once, injected 60 min after Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.)
Result:	Inhibited the catalepsy induced by Haloperidol (HY-14538).

Animal Model:	Male C57BL/6J mice (23-25 g)^[3]
Dosage:	0.3, 1 and 3 mg/kg
Administration:	IP, 1 h before the test
Result:	Significantly decreased the immobility time of mice in the tail suspension test (TST) by 24%, 41% and 48%, respectively. The efficacy of MTEP used at doses of 1 and 3 mg/kg was not significantly different from that of Imipramine (HY-B1490A) (20 mg/kg, ip), used as a positive standard.

Molecular Weight

236.72

Formula

C₁₁H₉ClN₂S

CAS No.

1186195-60-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=NC(C#CC2=CC=CN=C2)=CS1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 20 mg/mL (84.49 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2244 mL	21.1220 mL	42.2440 mL
5 mM	0.8449 mL	4.2244 mL	8.4488 mL
10 mM	0.4224 mL	2.1122 mL	4.2244 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (422.44 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.81%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (249 KB) LCMS (268 KB)

Handling Instructions (2659 KB)

References

[1]. Lea PM 4th, et al. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev. 2006 Summer;12(2):149-66. [Content Brief]

[2]. Ossowska K, et al. MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats. Neuropharmacology. 2005 Sep;49(4):447-55. [Content Brief]

[3]. Pałucha A, et al. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav. 2005 Aug;81(4):901-6. [Content Brief]

[4]. Klodzinska A, et al. Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling. Neuropharmacology. 2004 Sep;47(3):342-50. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.2244 mL	21.1220 mL	42.2440 mL	105.6100 mL
	5 mM	0.8449 mL	4.2244 mL	8.4488 mL	21.1220 mL
	10 mM	0.4224 mL	2.1122 mL	4.2244 mL	10.5610 mL
	15 mM	0.2816 mL	1.4081 mL	2.8163 mL	7.0407 mL
	20 mM	0.2112 mL	1.0561 mL	2.1122 mL	5.2805 mL
	25 mM	0.1690 mL	0.8449 mL	1.6898 mL	4.2244 mL
	30 mM	0.1408 mL	0.7041 mL	1.4081 mL	3.5203 mL
	40 mM	0.1056 mL	0.5281 mL	1.0561 mL	2.6403 mL
	50 mM	0.0845 mL	0.4224 mL	0.8449 mL	2.1122 mL
	60 mM	0.0704 mL	0.3520 mL	0.7041 mL	1.7602 mL
	80 mM	0.0528 mL	0.2640 mL	0.5281 mL	1.3201 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.