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Mastoparan, a tetradecapeptide which is a component of wasp venom, stimulates release of prolactin from cultured rat anterior pituitary cells.

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Custom Peptide Synthesis

Mastoparan Chemical Structure

Mastoparan Chemical Structure

CAS No. : 72093-21-1

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5 mg USD 225 In-stock
10 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

Mastoparan Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Mastoparan, a tetradecapeptide which is a component of wasp venom, stimulates release of prolactin from cultured rat anterior pituitary cells.

In Vitro

Mastoparan has an amphiphilic nature and is reported to exert a variety of pharmacological and biochemical effects. Mastoparan induces exocytosis of hormones from anterior pituitary cells. Mastoparan stimulation of prolactin secretion is dose-dependent, time-dependent, reversible and required the presence of calcium. Mastoparan causes translocation of protein kinase C activity from a soluble to a membrane-attached form. Mastoparan is able to increase the intracellular Ca2+ concentration in Fura-2-loaded individual lactotrophs. Mastoparan is also able to interact with GTP-bindmg proteins. Thus, Mastoparan has been shown to facilitate exchange of nucleotides and to stimulate GTPase activity on G-proteins. It has therefore been proposed that the cellular effects of Mastoparan are due to an ability to mimic G-protein-linked agonist-liganded receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mastoparan Related Antibodies
Molecular Weight

1478.91

Formula

C70H131N19O15
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
Sequence Shortening

INLKALAALAKKIL-NH2
Structure Classification
Initial Source

a wasp venom peptide
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (67.62 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6762 mL 3.3809 mL 6.7617 mL
5 mM 0.1352 mL 0.6762 mL 1.3523 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6762 mL 3.3809 mL 6.7617 mL 16.9043 mL
5 mM 0.1352 mL 0.6762 mL 1.3523 mL 3.3809 mL
10 mM 0.0676 mL 0.3381 mL 0.6762 mL 1.6904 mL
15 mM 0.0451 mL 0.2254 mL 0.4508 mL 1.1270 mL
20 mM 0.0338 mL 0.1690 mL 0.3381 mL 0.8452 mL
25 mM 0.0270 mL 0.1352 mL 0.2705 mL 0.6762 mL
30 mM 0.0225 mL 0.1127 mL 0.2254 mL 0.5635 mL
40 mM 0.0169 mL 0.0845 mL 0.1690 mL 0.4226 mL
50 mM 0.0135 mL 0.0676 mL 0.1352 mL 0.3381 mL
60 mM 0.0113 mL 0.0563 mL 0.1127 mL 0.2817 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mastoparan72093-21-1OthersInhibitorinhibitorinhibit

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