1. Metabolic Enzyme/Protease
  2. Isocitrate Dehydrogenase (IDH)
  3. Mutant IDH1-IN-1

Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.

For research use only. We do not sell to patients.

Mutant IDH1-IN-1 Chemical Structure

Mutant IDH1-IN-1 Chemical Structure

CAS No. : 1355326-21-4

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 209 In-stock
Solution
10 mM * 1 mL in DMSO USD 209 In-stock
Solid
5 mg USD 190 In-stock
10 mg USD 290 In-stock
50 mg USD 986 In-stock
100 mg USD 1590 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products
WB

    Mutant IDH1-IN-1 purchased from MedChemExpress. Usage Cited in: Sci Rep. 2017 Oct 6;7(1):12758.  [Abstract]

    Represented western blot of an isothermal dose-response at melting temperature of 59°C demonstrating cellular mIDH1 enzyme thermal stabilization with mIDH1 inhibitors.

    View All Isocitrate Dehydrogenase (IDH) Isoform Specific Products:

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    Description

    Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.

    IC50 & Target

    IDH1

     

    Molecular Weight

    498.59

    Formula

    C30H31FN4O2

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(C(C1=C(C)C=CC=C1)N(C(CN2C=NC3=C2C=CC=C3)=O)C4=CC(F)=CC=C4)NC5CCCCC5

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 45 mg/mL (90.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0057 mL 10.0283 mL 20.0566 mL
    5 mM 0.4011 mL 2.0057 mL 4.0113 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.0057 mL 10.0283 mL 20.0566 mL 50.1414 mL
    5 mM 0.4011 mL 2.0057 mL 4.0113 mL 10.0283 mL
    10 mM 0.2006 mL 1.0028 mL 2.0057 mL 5.0141 mL
    15 mM 0.1337 mL 0.6686 mL 1.3371 mL 3.3428 mL
    20 mM 0.1003 mL 0.5014 mL 1.0028 mL 2.5071 mL
    25 mM 0.0802 mL 0.4011 mL 0.8023 mL 2.0057 mL
    30 mM 0.0669 mL 0.3343 mL 0.6686 mL 1.6714 mL
    40 mM 0.0501 mL 0.2507 mL 0.5014 mL 1.2535 mL
    50 mM 0.0401 mL 0.2006 mL 0.4011 mL 1.0028 mL
    60 mM 0.0334 mL 0.1671 mL 0.3343 mL 0.8357 mL
    80 mM 0.0251 mL 0.1254 mL 0.2507 mL 0.6268 mL
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    Mutant IDH1-IN-1 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Mutant IDH1-IN-1
    Cat. No.:
    HY-12475
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