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  2. Alkaloid

Alkaloid

Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms, produced by a large variety of organisms including bacteria, fungi, plants, and animals. This group also includes some related compounds with neutral and even weakly acidic properties. Compounds like amino acid peptides, proteins, nucleotides, nucleic acid, amines, and antibiotics are usually not called alkaloids. Alkaloids have a wide range of pharmacological activities including antimalarial, antiasthma, anticancer, cholinomimetic, vasodilatory, antiarrhythmic, analgesic, antibacterial, and antihyperglycemic activities. Many have found use in traditional or modern medicine, or as starting points for drug discovery. Other alkaloids possess psychotropic and stimulant activities, and have been used in entheogenic rituals or as recreational drugs. Alkaloids can be toxic too. Although alkaloids act on a diversity of metabolic systems in humans and other animals, they almost uniformly evoke a bitter taste.

Alkaloid (187):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0488
    Vincristine sulfate 2068-78-2 99.40%
    Vincristine (sulfate) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.
    Vincristine sulfate
  • HY-12526
    Tetrodotoxin 4368-28-9 99.99%
    Tetrodotoxin is a highly selective sodium channel blocker, with IC50 of 33 nM for Nav1.6.
    Tetrodotoxin
  • HY-16569
    Colchicine 64-86-8 99.56%
    Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine triggers apoptosis.
    Colchicine
  • HY-10448
    Capsaicin 404-86-4 >98.0%
    Capsaicin is a TRPV1 agonist with EC50 of 0.29±0.05 μM in HEK293 cells.
    Capsaicin
  • HY-10820A
    Pemetrexed disodium 150399-23-8 99.04%
    Pemetrexed disodium is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.
    Pemetrexed disodium
  • HY-14944
    Homoharringtonine 26833-87-4
    Homoharringtonine is a cytotoxic alkaloid, induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells.
    Homoharringtonine
  • HY-16563
    Narciclasine 29477-83-6 99.94%
    Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
    Narciclasine
  • HY-12048
    Chelerythrine Chloride 3895-92-9 >98.0%
    Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C and mitogen-activated protein kinase (MAPK), with IC50 of 660 nM for PKC, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
    Chelerythrine Chloride
  • HY-B0638
    L-Nicotine 54-11-5 99.96%
    L-Nicotine is the prototype of nicotinic acetylcholine receptor agonists; natural isomer.
    L-Nicotine
  • HY-N0086
    N6-Methyladenosine 1867-73-8 99.51%
    N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes.
    N6-Methyladenosine
  • HY-10572
    Efavirenz 154598-52-4 99.69%
    Efavirenz is a potent inhibitor of the wild-type HIV-1 RT (Ki=2.93 nM) and exhibits IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.
    Efavirenz
  • HY-B0345A
    ATP disodium salt 987-65-5 98.47%
    ATP Disodium salt is a P2 purinoceptor agonist.
    ATP disodium salt
  • HY-N0296A
    Scopolamine hydrobromide 114-49-8 >98.0%
    Scopolamine hydrobromide is a high affinity (nM) muscarinic antagonist. 5-HT3 receptor-responses are reversibly inhibited by Scopolamine with an IC50 of 2.09 μM.
    Scopolamine hydrobromide
  • HY-B0282
    Acetylcholine chloride 60-31-1 >98.0%
    Acetylcholine is a neurotransmitter that can induce the opening of calcium channels.
    Acetylcholine chloride
  • HY-N0219
    (+)-Bicuculline 485-49-4 99.92%
    (+)-Bicuculline, a convulsant alkaloid, is the antagonist of GABA.
    (+)-Bicuculline
  • HY-N0737A
    Harmine 442-51-3 99.58%
    Harmine, a tricyclic b-carboline alkaloid that was originally isolated from seeds of Peganum harmala, has been reported to possess anxiolytic, behavioral effects.
    Harmine
  • HY-N0127
    Yohimbine Hydrochloride 65-19-0 99.79%
    Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.
    Yohimbine Hydrochloride
  • HY-N0304
    L-DOPA 59-92-7 99.72%
    L-DOPA is a natural form of DOPA used in the treatment of Parkinson's disease.
    L-DOPA
  • HY-B0809
    Theophylline 58-55-9 99.58%
    Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist.
    Theophylline
  • HY-N0095
    (S)-10-Hydroxycamptothecin 19685-09-7 99.20%
    (S)-10-Hydroxycamptothecin is a clinical therapy agent against hepatoma.
    (S)-10-Hydroxycamptothecin