1. Natural Products
  2. Flavonoids

Flavonoids

Flavonoids are a class of polyphenol secondary metabolites which are abundantly present in plants and diets. Flavonoids have the general structure of a 15-carbon skeleton, which consists of two phenyl rings (A and B) and heterocyclic ring (C). This carbon structure can be abbreviated C6-C3-C6. Depending on the structure of the C-ring, they can be divided into a variety of chemical classes such as flavones, flavonols, Chalcones, Isoflavanones, Anthocyans, Biflavones, and others, etc. Their classes differ in the level of oxidation and pattern of substitution of the pyran ring. Flavonoids have diverse biological activities which include, anti-oxidant activity, free radical scavenging activity, coronary heart disease prevention, hepatoprotective activity, anti-inflammatory, and anticancer activities, while some flavonoids also exhibit potential antiviral activities.

Flavonoids (1194):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-18085
    Quercetin 117-39-5 98.06%
    Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
    Quercetin
  • HY-N0162
    Luteolin 491-70-3 99.01%
    Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells.
    Luteolin
  • HY-13653
    (-)-Epigallocatechin Gallate 989-51-5 99.87%
    (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma.
    (-)-Epigallocatechin Gallate
  • HY-14590
    Kaempferol 520-18-3 99.86%
    Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer.
    Kaempferol
  • HY-14596
    Genistein 446-72-0 99.86%
    Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
    Genistein
  • HY-N2661
    5,7-Dihydroxy-3,4',8-trimethoxyflavone 1570-09-8 ≥98.0%
    5,7-Dihydroxy-3,4',8-trimethoxyflavone (Substance E) can be isolated from Conyza stricta Willd.
    5,7-Dihydroxy-3,4',8-trimethoxyflavone
  • HY-N10042
    Herbacetin 3,8-O-diglucoside 99224-12-1
    Herbacetin 3,8-O-diglucoside (Herbacetin di-glucoside) is a flavonol compound that can be found in flax seeds.
    Herbacetin 3,8-O-diglucoside
  • HY-N2529
    Sophoranone 23057-55-8 98.14%
    Sophoranone is a flavonoid compound that can be isolated from the root of Sophora subprostrata.
    Sophoranone
  • HY-N1201
    Apigenin 520-36-5 99.58%
    Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
    Apigenin
  • HY-N0197
    Baicalin 21967-41-9 99.17%
    Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of NF-κB.
    Baicalin
  • HY-N0196
    Baicalein 491-67-8 98.84%
    Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 μM.
    Baicalein
  • HY-N0182
    Fisetin 528-48-3 98.39%
    Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
    Fisetin
  • HY-N0148
    Rutin 153-18-4 98.06%
    Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress.
    Rutin
  • HY-N2117
    Isoginkgetin 548-19-6 99.95%
    Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy.
    Isoginkgetin
  • HY-N0183
    Formononetin 485-72-3 99.92%
    Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth.
    Formononetin
  • HY-N0145
    Puerarin 3681-99-0 99.42%
    Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.
    Puerarin
  • HY-15097
    Myricetin 529-44-2 98.52%
    Myricetin is a common plant-derived flavonoid with a wide range of activities including strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities.
    Myricetin
  • HY-N0400
    Wogonin 632-85-9 99.92%
    Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects.
    Wogonin
  • HY-N0102
    Isoliquiritigenin 961-29-5 98.02%
    Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.
    Isoliquiritigenin
  • HY-N0155
    Nobiletin 478-01-3 99.52%
    Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis.
    Nobiletin