Neomycin sulfate

Name: Neomycin sulfate
Brand: MedChemExpress
SKU: HY-B0470
Rating: 5.0 (23 reviews)

Cat. No.: HY-B0470 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis.

For research use only. We do not sell to patients.

Neomycin sulfate Chemical Structure

CAS No. : 1405-10-3

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
1 g	USD 35	In-stock	Estimated Time of Arrival: December 31
5 g	USD 52	In-stock	Estimated Time of Arrival: December 31
10 g	USD 60	In-stock	Estimated Time of Arrival: December 31
50 g		Get quote

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Customer Review

Based on 23 publication(s) in Google Scholar

Other Forms of Neomycin sulfate:

Framycetin In-stock
Neomycin Get quote

23 Publications Citing Use of MCE Neomycin sulfate

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•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

View All Isoforms

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

View All Phospholipase Isoform Specific Products:

View All Isoforms

Phospholipase A PLD

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Aminoglycoside

In Vitro

Neomycin is effective against most gram-negative organisms except Pseudomonas aeruginosa and anaerobic bacteria. Its activity against gram-positive microorganisms is more or less limited to staphylococci, but bacterial resistance supervenes after prolonged use^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

908.88

Formula

C₂₃H₅₂N₆O₂₅S₃

CAS No.

1405-10-3

Appearance

Solid

Color

White to light yellow

SMILES

O[C@H]1[C@H](O)[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)O[C@@H]1CN.[3H2SO4]

Structure Classification

Initial Source

Microorganisms

Micromonospora species

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (275.06 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1003 mL	5.5013 mL	11.0026 mL
5 mM	0.2201 mL	1.1003 mL	2.2005 mL
10 mM	0.1100 mL	0.5501 mL	1.1003 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (55.01 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (278 KB) SDS (419 KB)

COA (256 KB) HNMR (210 KB)

Handling Instructions (2659 KB)

References

[1]. Sasseville D. Neomycin. Dermatitis. 2010;21(1):3-7. [Content Brief]

[2]. Hu GF. Neomycin inhibits angiogenin-induced angiogenesis. Proc Natl Acad Sci U S A. 1998;95(17):9791-9795. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.1003 mL	5.5013 mL	11.0026 mL	27.5064 mL
	5 mM	0.2201 mL	1.1003 mL	2.2005 mL	5.5013 mL
	10 mM	0.1100 mL	0.5501 mL	1.1003 mL	2.7506 mL
	15 mM	0.0734 mL	0.3668 mL	0.7335 mL	1.8338 mL
	20 mM	0.0550 mL	0.2751 mL	0.5501 mL	1.3753 mL
	25 mM	0.0440 mL	0.2201 mL	0.4401 mL	1.1003 mL
	30 mM	0.0367 mL	0.1834 mL	0.3668 mL	0.9169 mL
	40 mM	0.0275 mL	0.1375 mL	0.2751 mL	0.6877 mL
	50 mM	0.0220 mL	0.1100 mL	0.2201 mL	0.5501 mL
	60 mM	0.0183 mL	0.0917 mL	0.1834 mL	0.4584 mL
	80 mM	0.0138 mL	0.0688 mL	0.1375 mL	0.3438 mL
	100 mM	0.0110 mL	0.0550 mL	0.1100 mL	0.2751 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.