1. Protein Tyrosine Kinase/RTK
  2. Btk

ONO-4059 hydrochloride (Synonyms: ONO4059 hydrochloride; ONO 4059 hydrochloride; GS4059 hydrochloride; GS 4059 hydrochloride; GS-4059 hydrochloride)

Cat. No.: HY-15771A Purity: 98.74%
Data Sheet SDS Handling Instructions

ONO-4059 is a selective and novel inhibitor of BTK with IC50 2.2 nm, ONO-4059 binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.

For research use only. We do not sell to patients.
ONO-4059 hydrochloride Chemical Structure

ONO-4059 hydrochloride Chemical Structure

CAS No. : 1439901-97-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO $121 In-stock
5 mg $110 In-stock
10 mg $180 In-stock
25 mg $350 In-stock
50 mg $550 In-stock
100 mg $850 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of ONO-4059 hydrochloride:

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Description

ONO-4059 is a selective and novel inhibitor of BTK with IC50 2.2 nm, ONO-4059 binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development. target:BTK. IC50:2.2 nm [1] BTK is potently inhibited by ONO/GS-4059 with a 50% inhibitory concentration of 2 nmol/L. ONO -4059 induces classical apoptosis at nanomolar concentrations in the activated B-cell diffuse large B-cell lymphoma (DLBCL) cell line, TMD-822 and in a TMD-8 xenograft model, treatment with ONO -4059 resulted in inhibition of tumor growth.[2]

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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0369 mL 10.1845 mL 20.3691 mL
5 mM 0.4074 mL 2.0369 mL 4.0738 mL
10 mM 0.2037 mL 1.0185 mL 2.0369 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

490.94

Formula

C₂₅H₂₃ClN₆O₃

CAS No.

1439901-97-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.74%

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Product Name:
ONO-4059 hydrochloride
Cat. No.:
HY-15771A
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