1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. OSIP-486823

OSIP-486823  (Synonyms: OSIP 486823; OSIP486823; CP248)

Cat. No.: HY-U00004 Purity: ≥98.0%
COA Handling Instructions

OSIP-486823 is a novel microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules.

For research use only. We do not sell to patients.

OSIP-486823 Chemical Structure

OSIP-486823 Chemical Structure

CAS No. : 200803-37-8

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Description

OSIP-486823 is a novel microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules.

IC50 & Target

Microtubule[1]

In Vitro

OSIP486823 inhibits growth and induce apoptosis in SW480 human colon cancer cells, with IC50 of 0.1 μM. OSIP-486823 (OSIP486823) causes depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells. Exisulind and the potent synthetic derivative OSIP-486823 are members of a new class of drugs known as selective apoptotic antineoplastic drugs that target cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE). OSIP-486823 also disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

473.54

Formula

C29H28FNO4

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NCC1=CC=CC=C1)CC(C2=C/3C=CC(F)=C2)=C(C)C3=C\C4=CC(OC)=C(OC)C(OC)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
Cell Assay
[1]

The SW480 human colon adenocarcinoma and NIH3T3 mouse fibroblast cell lines are seeded in six-well plates at a density of 3×104 per well, grown for 36 to 48 hours, and then exposed to increasing concentrations of each compound (e.g., OSIP-486823; 1, 2 and 4 μM) for 48 hours. Cell numbers are determined using a Coulter counter and results are expressed as a percentage of the control culture. All assays are done in triplicate. Data are analyzed in Excel and the IC50s are determined graphically from cell survival curves[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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OSIP-486823 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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