2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Orphenadrine hydrochloride

Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases.

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Orphenadrine hydrochloride Chemical Structure

Orphenadrine hydrochloride Chemical Structure

CAS No. : 341-69-5

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Orphenadrine hydrochloride Related Antibodies

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Description

Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases[1][2].

In Vitro

Orphenadrine hydrochloride (12 µM; 24.5 h) shows neuroprotective effects on 3-NPA-induced neurotoxicity cerebellar granule cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Orphenadrine hydrochloride Related Antibodies

Cell Viability Assay[1]

Cell Line: CGC cells (7-day-old Sprague Dawley rat)
Concentration: 6, 12, 24, 48 µM
Incubation Time: 24.5 h
Result: Prevented cells from 3-NPA induced cellular aggregation,volume diminution and neurite fragmentation.
In Vivo

Orphenadrine hydrochloride (10, 20, 30 mg/kg; i.p.; once aday for 3 days) reduces 3-NPA-induced mortality in a dose-dependent manner[1].
Orphenadrine hydrochloride (30 mg/kg; i.p.; once aday for 3 days) shows activity to against 3-NPA-induced neuronal damage in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley rats (275-300 g; 3-NPA toxicity model)[1].
Dosage: 10, 20, 30 mg/kg
Administration: Intraperitoneal injection; once aday for 3 days (30 min before 3-NPA)
Result: Reduced mortality of 3-NPA toxicity rats to 10-40% (3-NPA-treated animals showed general incoordination, drowsiness and general weakness).
Recovered 3-NPA-induced body weight loss, and when at 30 mg/kg reduced the level of PBR and expression of HSP27. (PBR and HSP27 are markers of neuronal damage).
Clinical Trial
Molecular Weight

305.84

Formula

C18H24ClNO
CAS No.
SMILES

CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Orphenadrine hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orphenadrine341-69-5iGluRIonotropic glutamate receptorsparkinson's syndromespasticityCGC cellsPBRHSP27neuroprotective propertiesInhibitorinhibitorinhibit

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