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Products are for research use only. Not for human use. We do not sell to patients.

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PF-3845

HY-14380

(PF 3845; PF3845)

PF-3845

PF-3845 Chemical Structure

PF-3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM); showing negligible activity against FAAH2.

Price and Availability of PF-3845

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Size Price Stock Quantity
10 mM * 1 mL $61 In-stock
5 mg $55 In-stock
10 mg $100 In-stock
50 mg $400 In-stock
100 mg $700 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL €60 In-stock
5 mg €54 In-stock
10 mg €98 In-stock
50 mg €392 In-stock
100 mg €686 In-stock
200 mg Get quote
500 mg Get quote

Discount Prices Available for Larger Orders.

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PF-3845 Data Sheet

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    Purity: 99.23%

  • Pdf Version Network Version

    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

Related Compound Libraries

Inhibitor Kit

Biological Activity of PF-3845

PF-3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM); showing negligible activity against FAAH2.
IC50 value: 0.23 uM
Target: FAAH
PF-3845 selectively inhibits FAAH by carbamylating FAAH's serine nucleophile [1]. PF-3845 treated mice (10 mg/kg, i.p.) shows rapid and complete inactivation of FAAH in the brain, as judged by competitive activity-based protein profiling (ABPP) with the serine hydrolase-directed probe fluorophosphonate (FP)-rhodamine. PF-3845 shows a long duration of action up to 24 hour. PF-3845-treated mice also shows dramatic (>10-fold) elevation in brain levels of AEA and other NAEs (N-pamitoyl ethanolamine [PEA] and N-oleoyl ethanolamine [OEA]). FAAH is AEA-degrading enzyme fatty acid amide hydrolase. PF-3845 (1–30 mg/kg, oral administration [p.o.]) causes a dose dependent inhibition of mechanical allodynia with a minimum effective dose (MED) of 3 mg/kg (rats are analyzed at 4 hour post dosing with PF-3845). At higher doses (10 and 30 mg/kg), PF-3845 inhibits pain responses to an equivalent, if not greater, degree than the nonsteroidal anti-inflammatory drug naproxen (10mg/kg, p.o.) [1]. PF-3845 (10 mg/kg, i.p.) significantly reverses LPS-induced tactile allodynia, but doesn't modify paw withdrawal thresholds in the saline-injected paw [2].

Chemical Information

M.Wt 456.46 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C24H23F3N4O2
CAS No 1196109-52-0
Solvent & Solubility

DMSO ≥90mg/mL Water <1.2mg/mL Ethanol ≥90mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.1908 mL 10.9539 mL 21.9077 mL
5 mM 0.4382 mL 2.1908 mL 4.3815 mL
10 mM 0.2191 mL 1.0954 mL 2.1908 mL

Clinical Information of PF-3845

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
PF-3845 Pfizer Inc Pain 30-NOV-09 31-MAY-10 Phase 2 27-NOV-12
Pfizer Inc Pain 31-MAY-09 31-JUL-09 Phase 1 14-JUL-09
Pfizer Inc 28-FEB-09 31-JUL-09 Phase 1 14-SEP-13
Pfizer Inc Pain 30-NOV-09 31-JAN-10 Phase 1 16-JUL-10
Pfizer Inc Pain 30-APR-10 30-JUN-10 Phase 1 25-JUL-10
Yale University Cannabis dependence 30-JUN-12 31-DEC-16 Phase 2 17-SEP-13

References on PF-3845

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    Biochanin A(Olmelin), an O-methylated isoflavone, is a natural organic compound in the class of phytochemicals known as flavonoids; inhibit FAAH with IC(50) values of 1.8/1.4/2.4 uM for mouse/Rat/Human FAAH respectively.

  • FAAH inhibitor 1

    FAAH inhibitor 1 is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 18(plusmn)8 nM.

  • FAAH-IN-2

    FAAH-IN-2 is a potent FAAH(fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2.

  • JZL195

    JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.

  • LY2183240

    LY2183240 is a novel and highly potent blocker of anandamide uptake (IC50 = 270 pM). LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM).

  • PF-04457845

    PF-04457845 is a potent and exquisitely selective inhibitor of FAAH, with an IC50 of 7.2 nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen.

  • URB-597

    URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets.