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Signaling Pathway

Paricalcitol

HY-50919

(Zemplar)

Paricalcitol

Paricalcitol Chemical Structure

Paricalcitol(Zemplar) is a drug used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.

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1 mg $550 In-stock
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1 mg €539 In-stock
5 mg €2156 In-stock
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Paricalcitol Data Sheet

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    Purity: 99.97%

  • Pdf Version Network Version

    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

Related Compound Libraries

Inhibitor Kit

Biological Activity of Paricalcitol

Paricalcitol(Zemplar) is a drug used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
IC50 value:
Target: Vd analog
Chemically, it is 19-nor-1,25-(OH)2-vitamin D2 or 19-nor-1,25-dihydroxyvitamin D2, being an analog of 1,25-dihydroxyergocalciferol, the active form of vitamin D2.

Chemical Information

M.Wt 416.64 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C27H44O3
CAS No 131918-61-1
Solvent & Solubility

10 mM in water

Clinical Information of Paricalcitol

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
Paricalcitol AbbVie Inc Secondary hyperparathyroidism 31-JUL-11 31-JAN-13 Phase 4 14-SEP-13
AbbVie Inc End stage renal disease 31-JAN-11 01-NOV-11 Phase 4 14-SEP-13
AbbVie Inc; Abbott Laboratories Secondary hyperparathyroidism 31-OCT-10 31-AUG-13 Phase 4 22-OCT-13
Steno Diabetes Center Cardiovascular disease 30-APR-10 30-APR-12 Phase 4 16-APR-12
AbbVie Inc End stage renal disease 31-MAY-12 30-SEP-14 Phase 4 22-NOV-13

References on Paricalcitol

  • Related VD/VDR Products

  • (24S)-24,25-Dihydroxyvitamin D3

    (24S)-24,25-Dihydroxycholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs.

  • 1alpha, 24, 25-Trihydroxy VD2

    1alpha, 24, 25-Trihydroxy VD2 is a vitamin D analog.

  • 1alpha, 25-Dihydroxy VD2-D6

    1alpha, 25-Dihydroxy VD2-D6 is a deuterated form of vitamin D.

  • 1alpha-Hydroxy VD4

    1alpha-Hydroxy VD4 , a 1alpha(OH)D derivative, can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU and P31/FUJ cells.

  • 24, 25-Dihydroxy VD2

    24, 25-Dihydroxy VD2 is a hydroxylated metabolite of Vitamin D2; a synthetic analog of Vitamin D.

  • 24, 25-Dihydroxy VD3

    24, 25-Dihydroxy VD3 is a compound which is closely related to 1,25-dihydroxyvitamin D3, the active form of vitamin D3, but like vitamin D3 itself and 25-hydroxyvitamin D3 is inactive as a hormone both in vitro and in vivo.

  • 24R-Calcipotriol

    24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

  • 25,26-Dihydroxyvitamin D3

    25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity.

  • 25-Hydroxy VD2-D6

    25-Hydroxy VD2-D6 is a labelled metabolite of Vitamin D2.

  • 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3

    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 derivative.

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