1. Cell Cycle/DNA Damage
  2. PPAR

Pemafibrate (Synonyms: (R)-K-13675)

Cat. No.: HY-17618 Purity: 99.78%
Handling Instructions

Pemafibrate is a novel selective PPARα modulator (SPPARMα) that has antihyperlipidaemic activity.

For research use only. We do not sell to patients.
Pemafibrate Chemical Structure

Pemafibrate Chemical Structure

CAS No. : 848259-27-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 427 In-stock
1 mg USD 132 In-stock
5 mg USD 396 In-stock
10 mg USD 600 In-stock
25 mg USD 1200 In-stock
50 mg USD 1920 In-stock
100 mg USD 2880 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Other Forms of Pemafibrate:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Pemafibrate is a novel selective PPARα modulator (SPPARMα) that has antihyperlipidaemic activity.

In Vitro

In primary human macrophages, pemafibrate promotes macrophage cholesterol efflux to HDL and exerts anti-inflammatory activities[1]. Pemafibrate is a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα) that possesses unique PPARα activity and selectivity, compared with placebo and fenofibrate in thosse with high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) levels[2].

In Vivo

Pemafibrate treatment decreases apoB secretion in chylomicrons by polarized Caco-2/TC7 intestinal epithelium cells and reduces triglyceride levels in apoE2KI mice. Pemafibrate treatment of hapoA-I tg mice increases plasma HDL cholesterol, apoA-I and stimulates RCT to feces. Pemafibrate also reduces markers of inflammation and macrophages in the aortic crosses as well as aortic atherosclerotic lesion burden in western diet-fed apoE2KI mice[1].

Clinical Trial
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0385 mL 10.1926 mL 20.3853 mL
5 mM 0.4077 mL 2.0385 mL 4.0771 mL
10 mM 0.2039 mL 1.0193 mL 2.0385 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Pemafibrate is suspended in carboxymethyl cellulose.

Female homozygous human apoE2KI mice, which express human apoE2 instead of mouse apoE and display a human-like lipoprotein profile, are fed a western diet containing (wt/wt) 0.2% cholesterol and 21% fat for 9 weeks and treated for the last 2 weeks with fenofibrate (250 mpk) or pemafibrate (0.1 or 1mpk) or carboxymethyl cellulose (CMC, control) (n=10/group). Blood is collected after 4 h-fasting by sinus retroorbital puncture under isoflurane-induced anaesthesia for biochemical analysis. Mice are euthanized by cervical dislocation and liver, aortic arch and intestinal epithelium are removed and snap-frozen until further analysis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility


* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.78%

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