2. Metabolic Enzyme/Protease Autophagy Anti-infection
  3. Phosphodiesterase (PDE) Autophagy HIV
  4. Pentoxifylline

Pentoxifylline  (Synonyms: BL-191; PTX; Oxpentifylline)

Cat. No.: HY-B0715 Purity: 99.92%
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Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation.

For research use only. We do not sell to patients.

Pentoxifylline Chemical Structure

Pentoxifylline Chemical Structure

CAS No. : 6493-05-6

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10 mM * 1 mL in DMSO
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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Pentoxifylline:

Pentoxifylline Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].

IC50 & Target

PDE[1]
In Vitro

Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner[3].
Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells[3].
Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells[3].
Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase[3].
Pentoxifylline results in high LC3-II/LC3-ratio[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pentoxifylline Related Antibodies

Cell Proliferation Assay[3]

Cell Line: MDA-MB-231 cells
Concentration: 0.1 mM, 1 mM, 5 mM , 10 mM, 50 mM
Incubation Time: 24 hours, 48 hours
Result: Inhibited cell proliferation in a dose-dependent manner.

Apoptosis Analysis[3]

Cell Line: MDA-MB-231 cells
Concentration: 0.5 mM
Incubation Time: 12 hours, 24 hours, 36 hours
Result: Induced apoptosis.

Cell Autophagy Assay[3]

Cell Line: MDA-MB-231 cells
Concentration: 0.5 mM
Incubation Time: 24 hours, 48 hours
Result: Induced approximately 20-28% of cell autophagy.

Cell Cycle Analysis[3]

Cell Line: MDA-MB-231 cells
Concentration: 0.5 mM
Incubation Time: 24 hours, 48 hours
Result: Induced G0/G1 phase arrest.

Western Blot Analysis[3]

Cell Line: MDA-MB-231 cells
Concentration: 0.5 mM
Incubation Time: 24 hours, 48 hours
Result: Induced high LC3-II/LC3-ratio.
In Vivo

Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and reduces cognitive impairment[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats 12-13-weeks-old (250-300 g)[4]
Dosage: 200 mg/kg
Administration: Intraperitoneal injection, at 1hr before and 3 hr after ischemia
Result: Significantly improved the spatial memory and effects were significant different from those of sham-operated and vehicle groups.
Clinical Trial
Molecular Weight

278.31

Formula

C13H18N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCCCC(C)=O)N(C)C2=C(N(C)C=N2)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 93.3 mg/mL (335.24 mM; Need ultrasonic and warming)

DMSO : ≥ 2.8 mg/mL (10.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5931 mL 17.9656 mL 35.9312 mL
5 mM 0.7186 mL 3.5931 mL 7.1862 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 110 mg/mL (395.24 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.92%

COA (247 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.5931 mL 17.9656 mL 35.9312 mL 89.8279 mL
5 mM 0.7186 mL 3.5931 mL 7.1862 mL 17.9656 mL
10 mM 0.3593 mL 1.7966 mL 3.5931 mL 8.9828 mL
H2O 15 mM 0.2395 mL 1.1977 mL 2.3954 mL 5.9885 mL
20 mM 0.1797 mL 0.8983 mL 1.7966 mL 4.4914 mL
25 mM 0.1437 mL 0.7186 mL 1.4372 mL 3.5931 mL
30 mM 0.1198 mL 0.5989 mL 1.1977 mL 2.9943 mL
40 mM 0.0898 mL 0.4491 mL 0.8983 mL 2.2457 mL
50 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.7966 mL
60 mM 0.0599 mL 0.2994 mL 0.5989 mL 1.4971 mL
80 mM 0.0449 mL 0.2246 mL 0.4491 mL 1.1228 mL
100 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.8983 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pentoxifylline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentoxifylline6493-05-6BL-191 PTX OxpentifyllineBL191BL 191Phosphodiesterase (PDE)AutophagyHIVHuman immunodeficiency virusmethyl-xanthineintermittentclaudicationimmunomodulatorhemorheologicalhemorrheologicdermatologicalperipheral vasculardiseasesvasculopathiesvasculitidesvenouslegulcerspigmentedpurpuricdermatosesleprosyanti-hypercholesterolemicInhibitorinhibitorinhibit

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