Physalaemin 

Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity.

Physalaemin (PHY), an undecapeptide with the sequence pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, is a member of the tachykinin family of neuropeptides. PHY is very close to the mammalian tachykinin substance P (SP) in its function and chemical composition, and SP is well studied and characterized^[1]. Physalaemin is a bradykinin potentiating peptide (BPP-5a)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1265.44

C₅₈H₈₄N₁₄O₁₆S

2507-24-6

GLP-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2

{Glp}-ADPNKFYGLM-NH2

OC(C=C1)=CC=C1C[C@@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H]3N(CCC3)C([C@H](CC(O)=O)NC([C@H](C)NC([C@H]4NC(CC4)=O)=O)=O)=O)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9.  [Content Brief]

  [2]. Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31.  [Content Brief]