2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. 5-HT Receptor Histamine Receptor
  4. Pimethixene

Pimethixene is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Pimethixene maleate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Pimethixene Chemical Structure

Pimethixene Chemical Structure

CAS No. : 314-03-4

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Pimethixene Related Antibodies

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Description

Pimethixene is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].

IC50 & Target[1]

5-HT2B Receptor

10.44 (pKi)

5-HT2A Receptor

10.22 (pKi)

5-HT2C Receptor

8.42 (pKi)

5-HT1A Receptor

7.63 (pKi)

M2 receptor

9.38 (pKi)

M1 receptor

8.61 (pKi)

D2 receptor

8.19 (pKi)

DD4.4 receptor

7.54 (pKi)

Molecular Weight

293.43

Formula

C19H19NS
CAS No.
SMILES

CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC=C4)C=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pimethixene Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pimethixene314-03-4Pimetixene5-HT ReceptorHistamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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