2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Pipequaline

Pipequaline  (Synonyms: PK-8165)

Cat. No.: HY-100140 Purity: 99.77%
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Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.

For research use only. We do not sell to patients.

Pipequaline Chemical Structure

Pipequaline Chemical Structure

CAS No. : 77472-98-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
5 mg USD 50 In-stock
10 mg USD 70 In-stock
50 mg USD 280 In-stock
100 mg USD 480 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Pipequaline:

Pipequaline Related Antibodies

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Description

Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity[1][2].

IC50 & Target

Benzodiazepine receptor[1]
In Vivo

Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

316.44

Formula

C22H24N2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C1(C2=CC=CC=C2)=NC3=CC=CC=C3C(CCC4CCNCC4)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (101.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1602 mL 15.8008 mL 31.6016 mL
5 mM 0.6320 mL 3.1602 mL 6.3203 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[3]

Rats: Pipequaline is dissolved in water to give injection volumes of 2 mL/kg. Rats are injected with 5, 10, and 50 mg/kg pipequaline. Infrared cells in the walls of the box provided automated measures of locomotor activity and rearing, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1602 mL 15.8008 mL 31.6016 mL 79.0039 mL
5 mM 0.6320 mL 3.1602 mL 6.3203 mL 15.8008 mL
10 mM 0.3160 mL 1.5801 mL 3.1602 mL 7.9004 mL
15 mM 0.2107 mL 1.0534 mL 2.1068 mL 5.2669 mL
20 mM 0.1580 mL 0.7900 mL 1.5801 mL 3.9502 mL
25 mM 0.1264 mL 0.6320 mL 1.2641 mL 3.1602 mL
30 mM 0.1053 mL 0.5267 mL 1.0534 mL 2.6335 mL
40 mM 0.0790 mL 0.3950 mL 0.7900 mL 1.9751 mL
50 mM 0.0632 mL 0.3160 mL 0.6320 mL 1.5801 mL
60 mM 0.0527 mL 0.2633 mL 0.5267 mL 1.3167 mL
80 mM 0.0395 mL 0.1975 mL 0.3950 mL 0.9875 mL
100 mM 0.0316 mL 0.1580 mL 0.3160 mL 0.7900 mL
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Pipequaline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pipequaline77472-98-1PK-8165PK8165PK 8165GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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