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Prifuroline is an antiarrhythmic agent.

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Prifuroline Chemical Structure

Prifuroline Chemical Structure

CAS No. : 70833-07-7

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Description

Prifuroline is an antiarrhythmic agent.

In Vivo

Prifuroline is an antiarrhythmic agent. Prifuroline dose-dependently antagonizes the arrhythmogenic action of aconitine in rats, when administered either intravenously (5, 10 or 20 mg/kg) or intraduodenally (10, 20 or 50 mg/kg). Prifuroline also diminishes ventricular susceptibility to electrical stimulation in open-chest rats. The arrhythmias induced in dogs by coronary artery ligation are markedly antagonized by Prifuroline after doses of 5 and 10 mg/kg i.v. or 30 mg/kg intraduodenally. The duration of its antiarrhythmic activity in this model of arrhythmias in conscious dogs is much longer after intraduodenal than after i.v. administration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

228.29

Formula

C14H16N2O
CAS No.
SMILES

CN(C)C1=NCC(C2=CC3=CC=CC=C3O2)C1
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Room temperature in continental US; may vary elsewhere.
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Prifuroline Related Classifications

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Keywords:

Prifuroline70833-07-7OthersInhibitorinhibitorinhibit

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