Pyrantel pamoate (Synonyms: Pyrantel embonate)

Cat. No.: HY-12640 Purity: 99.98%: FAQs
Data Sheet SDS COA Handling Instructions

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Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis.

For research use only. We do not sell to patients.

Pyrantel pamoate Chemical Structure

CAS No. : 22204-24-6

Size	Price	Stock	Quantity

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Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
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Other Forms of Pyrantel pamoate:

Pyrantel tartrate In-stock
Pyrantel Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Parasites^[1]^[2].

In Vitro

Pyrantel pamoate (10 nM-10 µM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	A. suum
Concentration:	10 nM-10 µM
Incubation Time:	72 h
Result:	Inhibited A. suum with a pEC₅₀ value of 7.24.

Cell Viability Assay^[2]

Cell Line:	N. americanus
Concentration:	0-168.2 M (0-100 µg/mL)
Incubation Time:	72 h
Result:	Inhibited third-stage larvae and adult of N. americanus with IC₅₀ values of 2.0 and 7.6 mg/mL, respectively.

In Vivo

Pyrantel pamoate (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected)^[2].
Dosage:	10 mg/kg
Administration:	Oral administration; single.
Result:	Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.

Clinical Trial

Molecular Weight

594.68

Formula

C₃₄H₃₀N₂O₆S

CAS No.

22204-24-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(O)C(CC2=C3C=CC=CC3=CC(C(O)=O)=C2O)=C4C=CC=CC4=C1)O.CN5CCCN=C5/C=C/C6=CC=CS6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 20.83 mg/mL (35.03 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6816 mL	8.4079 mL	16.8158 mL
5 mM	0.3363 mL	1.6816 mL	3.3632 mL
10 mM	0.1682 mL	0.8408 mL	1.6816 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.20 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (279 KB) SDS (393 KB)

COA (256 KB) HNMR (302 KB) LCMS (274 KB)

Handling Instructions (2659 KB)

References

[1]. Martin RJ, et, al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol. 2004 Aug;34(9):1083-90. [Content Brief]

[2]. Tritten L, et, al. In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS Negl Trop Dis. 2011 Dec;5(12):e1457. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6816 mL	8.4079 mL	16.8158 mL	42.0394 mL
	5 mM	0.3363 mL	1.6816 mL	3.3632 mL	8.4079 mL
	10 mM	0.1682 mL	0.8408 mL	1.6816 mL	4.2039 mL
	15 mM	0.1121 mL	0.5605 mL	1.1211 mL	2.8026 mL
	20 mM	0.0841 mL	0.4204 mL	0.8408 mL	2.1020 mL
	25 mM	0.0673 mL	0.3363 mL	0.6726 mL	1.6816 mL
	30 mM	0.0561 mL	0.2803 mL	0.5605 mL	1.4013 mL

Pyrantel pamoate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyrantel22204-24-6Pyrantel embonateParasitenAChRAntibioticNicotinic acetylcholine receptorsparasitic infectionascariasishookwormpinwormtrichinosisInhibitorinhibitorinhibit

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