2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Pyrithioxin dihydrochloride

Pyrithioxin dihydrochloride  (Synonyms: Pyritinol dihydrochloride; Pyridoxine disulfide dihydrochloride; Vitamin B6 disulfide dihydrochloride)

Cat. No.: HY-B0910A Purity: ≥98.0%
COA Handling Instructions

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Pyrithioxin dihydrochloride is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia.

For research use only. We do not sell to patients.

Pyrithioxin dihydrochloride Chemical Structure

Pyrithioxin dihydrochloride Chemical Structure

CAS No. : 10049-83-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in Water USD 66 In-stock
Solid
100 mg USD 60 In-stock
500 mg USD 90 In-stock
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5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Pyrithioxin dihydrochloride:

Pyrithioxin dihydrochloride Related Antibodies

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Description

Pyrithioxin dihydrochloride is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia.

IC50 & Target

Human Endogenous Metabolite

 

Clinical Trial
Molecular Weight

441.39

Formula

C16H22Cl2N2O4S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC1=C(CSSCC2=C(CO)C(O)=C(C)N=C2)C=NC(C)=C1O.[H]Cl.[H]Cl
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (151.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (113.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2656 mL 11.3279 mL 22.6557 mL
5 mM 0.4531 mL 2.2656 mL 4.5311 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 11.11 mg/mL (25.17 mM); Clear solution; Need ultrasonic and adjust pH to 1 with 1M HCl

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.2656 mL 11.3279 mL 22.6557 mL 56.6393 mL
5 mM 0.4531 mL 2.2656 mL 4.5311 mL 11.3279 mL
10 mM 0.2266 mL 1.1328 mL 2.2656 mL 5.6639 mL
15 mM 0.1510 mL 0.7552 mL 1.5104 mL 3.7760 mL
20 mM 0.1133 mL 0.5664 mL 1.1328 mL 2.8320 mL
25 mM 0.0906 mL 0.4531 mL 0.9062 mL 2.2656 mL
30 mM 0.0755 mL 0.3776 mL 0.7552 mL 1.8880 mL
40 mM 0.0566 mL 0.2832 mL 0.5664 mL 1.4160 mL
50 mM 0.0453 mL 0.2266 mL 0.4531 mL 1.1328 mL
60 mM 0.0378 mL 0.1888 mL 0.3776 mL 0.9440 mL
80 mM 0.0283 mL 0.1416 mL 0.2832 mL 0.7080 mL
100 mM 0.0227 mL 0.1133 mL 0.2266 mL 0.5664 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pyrithioxin dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyrithioxin10049-83-9PyritinolPyridoxine disulfideVitamin B6 disulfideEndogenous MetaboliteInhibitorinhibitorinhibit

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