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Cat. No.: HY-12762
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QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor.

For research use only. We do not sell to patients.
QS11 Chemical Structure

QS11 Chemical Structure

CAS No. : 944328-88-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $112 In-stock
5 mg $90 In-stock
10 mg $160 In-stock
25 mg $360 In-stock
50 mg $640 In-stock
100 mg $1100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor.

In Vitro

QS11 binds and inhibits the GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), suggesting that QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 (2.5 μM) activates the Super(8X)TOPFlash reporter 200-fold in the presence of Wnt-3a CM, whereas Wnt-3a treatment alone increases reporter activity 40-fold. QS11 increases reporter activity only 2-fold in the absence of Wnt-3a. QS11 shows potent activity (EC50=0.5 μM) with little cytotoxicity toward HEK293 and human primary fibroblast cells. QS11 effectively reduces in vitro migration of metastatic human breast cancer cells[1].

Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.7616 mL 8.8078 mL 17.6156 mL
5 mM 0.3523 mL 1.7616 mL 3.5231 mL
10 mM 0.1762 mL 0.8808 mL 1.7616 mL
Cell Assay

ARF-GTP levels are measured by using the GGA binding assay. NIH 3T3 cells are treated with QS11 or QS11-NC at the indicated concentrations for 36 h. Cells are lysed in ARF assay lysis buffer [50 mM Tris·HCl (pH 7.5), 100 mM NaCl, 2 mM MgCl2, 0.1% SDS, 0.5% sodium deoxycholate, 1% Triton X-100, 10% glycerol, and protease inhibitors]. GTP-bound ARF is assayed by its binding to a GST fusion protein, which contains the VHS domain to the GAT region of an ARF effector GGA3[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.








Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 10 mM

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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