1. Neurological Disease

Neurological Disease

A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Neurological Disease Related Products (891):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15608
    MPTP hydrochloride 23007-85-4
    MPTP (hydrochloride) is a prodrug to the neurotoxin MPP which causes permanent symptoms of Parkinson's disease.
    MPTP hydrochloride
  • HY-13027
    DAPT 208255-80-5
    DAPT is a γ-secretase inhibitor, reduces the total beta-amyloid peptide () production with IC50 of 20 nM in HEK 293 cells.
  • HY-17366
    Clozapine N-oxide 34233-69-7
    Clozapine N-oxide is a pharmacologically inert metabolite of Clozapine, which is a potent 5-HT1C receptor antagonist. Clozapine N-oxide (CNO) is a DREADD (designer receptors exclusively activated by designer drug) agonist.
    Clozapine N-oxide
  • HY-12012
    SB 216763 280744-09-4
    SB 216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor, with IC50 value of 34 nM.
    SB 216763
  • HY-15084
    (+)-MK 801 (Maleate) 77086-22-7
    (+)-MK 801 (Maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
    (+)-MK 801 (Maleate)
  • HY-B0726
    Pilocarpine Hydrochloride 54-71-7
    Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.
    Pilocarpine Hydrochloride
  • HY-15441
    PF-04447943 1082744-20-4
    PF-04447943 is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM).
  • HY-12526
    Tetrodotoxin 4368-28-9
    Tetrodotoxin is a highly selective sodium channel blocker, with IC50 of 33 nM for Nav1.6.
  • HY-13240
    LY2886721 1262036-50-9
    LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease.
  • HY-13291
    WIN 55,212-2 Mesylate 131543-23-2
    WIN 55,212-2 (Mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively.
    WIN 55,212-2 Mesylate
  • HY-10095
    Olcegepant 204697-65-4
    Olcegepant is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM.
  • HY-15421
    AM630 164178-33-0
    AM630 is a selective CB2 antagonist with Ki of 31.2 nM, and displays 165-fold selectivity over CB1 receptors.
  • HY-15443
    AM251 183232-66-8
    AM251 is a selective cannabinoid (CB)1 receptor antagonist with IC50 of 8 nM, also acts as an agonist at micromolar concentration.
  • HY-75766
    Methylnaltrexone Bromide 73232-52-7
    Methylnaltrexone (Bromide) is a peripheral-acting opioid receptor antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation.
    Methylnaltrexone Bromide
  • HY-10889
    Preladenant 377727-87-2
    Preladenant is a potent competitive antagonist of the human A2A receptor (Ki=1.1 nM) and has >1000-fold selectivity over all other adenosine receptors.
  • HY-12723A
    Apomorphine hydrochloride hemihydrate 41372-20-7
    Apomorphine hydrochloride hemihydrate is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes.
    Apomorphine hydrochloride hemihydrate
  • HY-B0407A
    Chlorpromazine hydrochloride 69-09-0
    Chlorpromazine Hydrochloride is an antagonist of the dopamine D2 receptors, 5-HT2A receptors, potassium channel, sodium channel, with Ki of 363 nM and 8.3 nM for dopamine D2 receptor and serotonin 5-HT2A receptor, respectively.
    Chlorpromazine hydrochloride
  • HY-14557
    Pimavanserin 706779-91-1
    Pimavanserin is a potent 5-hydroxytryptamine (5-HT)2A receptor inverse agonist, displays potent inverse agonist activity in the cell-based functional assay receptor selection and amplification technology (R-SAT), with a mean pIC50 of 8.7.
  • HY-76299
    Galanthamine 357-70-0
    Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with IC50 of 500 nM.
  • HY-32709
    MK-0974 781649-09-0
    MK-0974 is a highly potent, selective, and orally bioavailable CGRP receptor antagonist with Ki values of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively, but displays > 1500-fold lower affinity for the canine and rat receptors.