2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. 5-HT Receptor Cytochrome P450
  4. Revexepride

Revexepride is a highly selective 5-HT4 receptor agonist, and a potential inducer of CYP3A4 enzyme, used for the treatment of gastroesophageal reflux disease.

For research use only. We do not sell to patients.

Revexepride Chemical Structure

Revexepride Chemical Structure

CAS No. : 219984-49-3

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1 mg USD 680 In-stock
5 mg USD 1700 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Revexepride Related Antibodies

Top Publications Citing Use of Products

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP3A4 CYP17A1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Revexepride is a highly selective 5-HT4 receptor agonist, and a potential inducer of CYP3A4 enzyme, used for the treatment of gastroesophageal reflux disease.

IC50 & Target

5-HT4 Receptor

 

CYP3A4

 

In Vitro

The human CYP isoenzymes are involved in the metabolism of revexepride, which is mainly metabolized in vitro in humans by CYP3A4 (99.9%) with a minor contribution of CYP2D6 (0.1%). Revexepride exhibits direct inhibition of human CYP3A4 in vitro with IC50 values of 16-49 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Revexepride Related Antibodies
Molecular Weight

425.95

Formula

C21H32ClN3O4
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=C(OC(C)(C)C2)C2=C(N)C(Cl)=C1)NC[C@H]3[C@H](O)CN(CCCOC)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (234.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3477 mL 11.7385 mL 23.4769 mL
5 mM 0.4695 mL 2.3477 mL 4.6954 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.84%

COA (250 KB) HNMR (245 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3477 mL 11.7385 mL 23.4769 mL 58.6923 mL
5 mM 0.4695 mL 2.3477 mL 4.6954 mL 11.7385 mL
10 mM 0.2348 mL 1.1738 mL 2.3477 mL 5.8692 mL
15 mM 0.1565 mL 0.7826 mL 1.5651 mL 3.9128 mL
20 mM 0.1174 mL 0.5869 mL 1.1738 mL 2.9346 mL
25 mM 0.0939 mL 0.4695 mL 0.9391 mL 2.3477 mL
30 mM 0.0783 mL 0.3913 mL 0.7826 mL 1.9564 mL
40 mM 0.0587 mL 0.2935 mL 0.5869 mL 1.4673 mL
50 mM 0.0470 mL 0.2348 mL 0.4695 mL 1.1738 mL
60 mM 0.0391 mL 0.1956 mL 0.3913 mL 0.9782 mL
80 mM 0.0293 mL 0.1467 mL 0.2935 mL 0.7337 mL
100 mM 0.0235 mL 0.1174 mL 0.2348 mL 0.5869 mL
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Revexepride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Revexepride219984-49-35-HT ReceptorCytochrome P450Serotonin Receptor5-hydroxytryptamine ReceptorCYPsInhibitorinhibitorinhibit

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