1. Autophagy
  2. ULK

SBI-0206965 

Cat. No.: HY-16966 Purity: 98.04%
Data Sheet SDS Handling Instructions

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 .

For research use only. We do not sell to patients.
SBI-0206965 Chemical Structure

SBI-0206965 Chemical Structure

CAS No. : 1884220-36-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
5 mg USD 120 In-stock
10 mg USD 180 In-stock
50 mg USD 540 In-stock
100 mg USD 780 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 . IC50 value: 108nM/711 nM Target: ULK1/ ULK2 in vitro: SBI-0206965 has very high selectivity, only inhibits 10 out of 456 kinases >95% when tested at 10 μM. SBI-0206965 suppressed ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival It can suppress autophagy induced by mTOR inhibition, prevent ULK1-dependent cell survival following nutrient deprivation. It greatly synergized with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells, providing a strong rationale for their combined use in the clinic.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0437 mL 10.2183 mL 20.4365 mL
5 mM 0.4087 mL 2.0437 mL 4.0873 mL
10 mM 0.2044 mL 1.0218 mL 2.0437 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

489.32

Formula

C₂₁H₂₁BrN₄O₅

CAS No.

1884220-36-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.04%

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Product Name:
SBI-0206965
Cat. No.:
HY-16966
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