2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. SGD-1882

SGD-1882  (Synonyms: PBD dimer)

Cat. No.: HY-101127 Purity: 98.45%
COA Handling Instructions

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SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

For research use only. We do not sell to patients.

SGD-1882 Chemical Structure

SGD-1882 Chemical Structure

CAS No. : 1222490-34-7

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1 mg USD 2900 In-stock
5 mg USD 6800 In-stock
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Based on 1 publication(s) in Google Scholar

SGD-1882 Related Antibodies

Top Publications Citing Use of Products

View All ADC Cytotoxin Isoform Specific Products:

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Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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  • Purity & Documentation

  • References

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Description

SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

In Vitro

SGD-1882 is the cytotoxic payload undergoing clinical evaluation for anti-CD33 and anti-CD70 conjugates[1]. SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SGD-1882 Related Antibodies
Molecular Weight

725.79

Formula

C42H39N5O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC(OC)=C(OCCCOC(C=C(N=C[C@@]2([H])N(C=C(C3=CC=C(N)C=C3)C2)C4=O)C4=C5)=C5OC)C=C1N=C6)N7[C@@]6([H])CC(C8=CC=C(OC)C=C8)=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (137.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3778 mL 6.8890 mL 13.7781 mL
5 mM 0.2756 mL 1.3778 mL 2.7556 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.45%

COA (244 KB) LCMS (259 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3778 mL 6.8890 mL 13.7781 mL 34.4452 mL
5 mM 0.2756 mL 1.3778 mL 2.7556 mL 6.8890 mL
10 mM 0.1378 mL 0.6889 mL 1.3778 mL 3.4445 mL
15 mM 0.0919 mL 0.4593 mL 0.9185 mL 2.2963 mL
20 mM 0.0689 mL 0.3445 mL 0.6889 mL 1.7223 mL
25 mM 0.0551 mL 0.2756 mL 0.5511 mL 1.3778 mL
30 mM 0.0459 mL 0.2296 mL 0.4593 mL 1.1482 mL
40 mM 0.0344 mL 0.1722 mL 0.3445 mL 0.8611 mL
50 mM 0.0276 mL 0.1378 mL 0.2756 mL 0.6889 mL
60 mM 0.0230 mL 0.1148 mL 0.2296 mL 0.5741 mL
80 mM 0.0172 mL 0.0861 mL 0.1722 mL 0.4306 mL
100 mM 0.0138 mL 0.0689 mL 0.1378 mL 0.3445 mL
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SGD-1882 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGD-18821222490-34-7PBD dimerSGD1882SGD 1882ADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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