1. Protein Tyrosine Kinase/RTK
  2. TAM Receptor

SGI-7079 

Cat. No.: HY-12964 Purity: 98.18%
Data Sheet SDS Handling Instructions

SGI-7079 is an Axl inhibitor, significantly inhibits the proliferation of SUM149 or KPL-4 cells with an IC50 of 0.43 or 0.16 μM, respectively.

For research use only. We do not sell to patients.
SGI-7079 Chemical Structure

SGI-7079 Chemical Structure

CAS No. : 1239875-86-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 119 In-stock
5 mg USD 108 In-stock
10 mg USD 180 In-stock
50 mg USD 660 In-stock
100 mg USD 960 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

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Description

SGI-7079 is an Axl inhibitor, significantly inhibits the proliferation of SUM149 or KPL-4 cells with an IC50 of 0.43 or 0.16 μM, respectively. Ic50 value: Target: Axl in vitro: SGI-7079 treatment inhibits the phosphorylation of Axl at Tyr 702 upon Gas6 stimulation in SUM149 cells. The growth of SUM149 and KPL-4 in soft agar, one of the hallmark characteristics of cellular transformation and uncontrolled cell growth, is also significantly inhibited by SGI-7079 treatment. SGI-7079 treatment also significantly decreases the migration and invasion of SUM149 cells and the invasion of KPL-4 cells. Taken together, Axl inhibitor SGI-7079 significantly inhibits the proliferation, migration, and invasion of IBC cells, suggesting that Axl may be a promising therapeutic target in patients with IBC. [1] in vivo: SGI-7079 inhibits tumor growth in a dose dependent manner, and at the maximum dose, inhibited tumor growth by 67%, compared to control. The combined inhibition of Axl (SGI-7079) plus EGFR (Erlotinib) is significantly more effective than either drug alone. Notably, SGI-7079 + Erlotinib (25/100 mg/kg) reduced the tumor growth by 82%. Axl blockade by SGI-7079 inhibits the growth of mesenchymal NSCLC xenograft tumors. [2]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.1952 mL 10.9762 mL 21.9525 mL
5 mM 0.4390 mL 2.1952 mL 4.3905 mL
10 mM 0.2195 mL 1.0976 mL 2.1952 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

455.53

Formula

C₂₆H₂₆FN₇

CAS No.

1239875-86-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 34 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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SGI-7079
Cat. No.:
HY-12964
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