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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

SU11274

HY-12014

(SU 11274; PKI-SU11274; SU-11274)

SU11274

SU11274 Chemical Structure

SU11274(PKI-SU11274) is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFRβ, EGFR or Tie2.

Price and Availability of SU11274

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Size Price Stock Quantity
10 mM * 1 mL $169 In-stock
10 mg $154 In-stock
50 mg $564 In-stock
100 mg $715 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL €166 In-stock
10 mg €151 In-stock
50 mg €553 In-stock
100 mg €701 In-stock
200 mg Get quote
500 mg Get quote

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SU11274 Data Sheet

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    Purity: 97.78%

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Related Compound Libraries

Inhibitor Kit

Biological Activity of SU11274

SU11274(PKI-SU11274) is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFRβ, EGFR or Tie2.
IC50 value: 10 nM [1]
Target: Met
in vitro: SU11274 exhibits greater than 50-fold selectivity for Met versus Flk and more than 500 times selectivity versus other tyrosine kinases such as FGFR-1, c-src, PDGFbR, and EGFR. SU11274 inhibits the phosphorylation of key regulators of the PI3K pathway, including AKT, FKHR, or GSK3β. SU11274 treatment inhibits the growth of TPR-MET-transformed BaF3 cells in a dose-dependent manner with IC50 of <3 μM in the absence of interleukin 3, without growth inhibition of BaF3 cells transformed by other oncogenic tyrosine kinases, including BCR-ABL, TEL-JAK2, TEL-ABL, and TEL-PDGFβR. In addition to cell growth, SU11274 treatment significantly inhibits the migration of BaF3. TPR-MET cells by 44.8% and 80% at 1 μM and 5 μM, respectively. SU11274 inhibits HGF-dependent phosphorylation of Met as well as HGF-dependent cell proliferation and motility with an IC50 of 1-1.5 μM. In H69 and H345 cells which have functional Met receptor, SU11274 inhibits the HGF-induced cell growth with IC50 of 3.4 μM and 6.5 μM, respectively. SU11274 induces G1 cell cycle arrest with cells in G1 phase increased from 42.4% to 70.6% at 5 μM, and induces caspase-dependent apoptosis by 24% at 1 μM [2]. SU11274 inhibits cell viability in c-Met-expressing non-small cell lung cancer (NSCLC) cells with IC50 values of 0.8-4.4 μM, and abrogates hepatocyte growth factor-induced phosphorylation of c-Met and its downstream signaling [3].

Chemical Information

M.Wt 568.09 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C28H30ClN5O4S
CAS No 658084-23-2
Solvent & Solubility

DMSO ≥90mg/mL Water <1.2mg/mL Ethanol ≥1.8mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.7603 mL 8.8014 mL 17.6028 mL
5 mM 0.3521 mL 1.7603 mL 3.5206 mL
10 mM 0.1760 mL 0.8801 mL 1.7603 mL

References on SU11274

  • Related c-Met/HGFR Products

  • Altiratinib

    Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro.

  • AMG-208

    AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.

  • BMS 777607

    BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.

  • BMS-794833

    BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7/15 nM; also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378.

  • c-Met inhibitor 1

    c-Met inhibitor 1 is an inhibitor of the c-Met receptor signaling pathway useful for the treatment of cancer including gastric, glioblastoma, and pancreatic cancer.

  • E-7050

    E7050(Golvatinib) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM.

  • EMD-1214063

    EMD 1214063 is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer.

  • Foretinib

    Foretinib (GSK1363089; XL880; EXEL-2880; GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFR(alpha)/(beta) and Tie-2, and little activity to FGFR1 and EGFR.

  • INCB28060

    INCB28060 is a novel orally active inhibitor (IC50=0.13 nM) of c-MET kinase.

  • JNJ-38877605

    JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.

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