Sapropterin dihydrochloride (Synonyms: (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride)

Name: Sapropterin dihydrochloride
Brand: MedChemExpress
SKU: HY-A0124A
Rating: 4.5 (2 reviews)

Cat. No.: HY-A0124A Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin also drives autoimmunity. Sapropterin can be used in study of phenylketonuria (PKU).

For research use only. We do not sell to patients.

Sapropterin dihydrochloride Chemical Structure

CAS No. : 69056-38-8

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 38	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 96	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 168	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Sapropterin dihydrochloride:

Tetrahydrobiopterin In-stock
Sapropterin Get quote

2 Publications Citing Use of MCE Sapropterin dihydrochloride

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Description

In Vivo

Sapropterin (2 mg/kg/d, p.o., 19 d) aggravates experimental autoimmune encephalomyelitis (EAE) in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

314.17

Formula

C₉H₁₇Cl₂N₅O₃

CAS No.

69056-38-8

Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(N)NC2=C1N[C@@H]([C@@H](O)[C@@H](O)C)CN2.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 200 mg/mL (636.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (318.30 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1830 mL	15.9150 mL	31.8299 mL
5 mM	0.6366 mL	3.1830 mL	6.3660 mL
10 mM	0.3183 mL	1.5915 mL	3.1830 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (318.30 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (251 KB) HNMR (255 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Sanford M, et al. Sapropterin: a review of its use in the treatment of primary hyperphenylalaninaemia. Drugs. 2009;69(4):461-76. [Content Brief]

[2]. Schmitz K, et al. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics. 2021 Jul;18(3):1862-1879. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.1830 mL	15.9149 mL	31.8299 mL	79.5747 mL
	5 mM	0.6366 mL	3.1830 mL	6.3660 mL	15.9149 mL
	10 mM	0.3183 mL	1.5915 mL	3.1830 mL	7.9575 mL
	15 mM	0.2122 mL	1.0610 mL	2.1220 mL	5.3050 mL
	20 mM	0.1591 mL	0.7957 mL	1.5915 mL	3.9787 mL
	25 mM	0.1273 mL	0.6366 mL	1.2732 mL	3.1830 mL
	30 mM	0.1061 mL	0.5305 mL	1.0610 mL	2.6525 mL
	40 mM	0.0796 mL	0.3979 mL	0.7957 mL	1.9894 mL
	50 mM	0.0637 mL	0.3183 mL	0.6366 mL	1.5915 mL
	60 mM	0.0530 mL	0.2652 mL	0.5305 mL	1.3262 mL
	80 mM	0.0398 mL	0.1989 mL	0.3979 mL	0.9947 mL
	100 mM	0.0318 mL	0.1591 mL	0.3183 mL	0.7957 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sapropterin69056-38-8(6R)-BH4(6R)-Tetrahydro-L-biopterinOthersPKUPAHphenylalanine hydroxylaseInhibitorinhibitorinhibit

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Sapropterin dihydrochloride (Synonyms: (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride)

Customer Review

Other Forms of Sapropterin dihydrochloride:

Sapropterin dihydrochloride Related Antibodies

2 Publications Citing Use of MCE Sapropterin dihydrochloride

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

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