Sardomozide (Synonyms: CGP 48664; SAM-486A)

Cat. No.: HY-13746: FAQs
Data Sheet Handling Instructions

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Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC₅₀ of 5 nM.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Sardomozide dihydrochloride) usually boasts enhanced water solubility and stability.

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Sardomozide Chemical Structure

CAS No. : 149400-88-4

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Other In-stock Forms of Sardomozide:

Sardomozide dihydrochloride

Other Forms of Sardomozide:

Sardomozide dihydrochloride In-stock

2 Publications Citing Use of MCE Sardomozide

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Biological Activity
Protocol
Purity & Documentation
References
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Description	Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC₅₀ of 5 nM.
IC₅₀ & Target	IC50: 5 nM (SAMDC)^[1]
In Vitro	Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC₅₀ of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control^[1]. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Sardomozide Related Antibodies
Molecular Weight	230.27
Formula	C₁₁H₁₄N₆
CAS No.	149400-88-4
SMILES	N=C(C1=CC=CC2=C1CC/C2=N\NC(N)=N)N
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7. [Content Brief] [2]. Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90. [Content Brief]

Cell Assay
^[2]

The parent CHO cell line is chronically exposed to increasing levels of Sardomozide for at least eight passages beginning at 0.1 μM. Cell lines are serially exposed to increasing concentrations until a panel of sublines is obtained resistant to 1 (CHO/1). 3 (CHO/3), 10 (CHO/10), 30 (CHO/30), and 100 (CHO/100) μM Sardomozide for comparative studies^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7. [Content Brief]

[2]. Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90. [Content Brief]

Sardomozide Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sardomozide149400-88-4CGP 48664 SAM-486ACGP48664CGP-48664OthersInhibitorinhibitorinhibit

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